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Cat. No.: HY-P87492

RanBP3 Antibody (YA7179)

RanBP3 Antibody (YA7179) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RanBP3.

For research use only. We do not sell to patients.

Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	IHC-F IHC-F: Immunohistochemistry-Frozen	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	FC FC: Flow Cytometry	IP IP: Immunoprecipitation
Dilution Ratio	1:1000-2000	1:100-200	1:100-200	1:50-200	1:50-100	1:20-50

Description

RanBP3 Antibody (YA7179) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RanBP3.

Host Rabbit
Clonality Recombinant
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 70 or 90kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 60kDa

Immunogen

A synthesized peptide derived from human RanBP3

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

RanBP3 acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export
Subcellular Localization

Cytoplasm,Nucleus
Expression

Tissue_Specificity: Widely expressed with high levels in testis and heart
Isoforms & Post-Translational Modification

Q9H6Z4 has three isomers: Q9H6Z4-1: 60210 Da (predicted); Q9H6Z4-2: 59694 Da (predicted); Q9H6Z4-3: 53411 Da (predicted).
Phosphorylation at Ser-126 promotes its import into the nucleus
Subunit

Interacts with CHC1 in a Ran-stimulated manner
SwissProt ID

Q9H6Z4