2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Ron Antibody (YA5046)

Ron Antibody (YA5046) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Ron.

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容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

Ron Antibody (YA5046) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Ron.
Host

Rabbit
Clonality

Monoclonal,Recombinant
分子量
Predicted band size: 152 kDa;
Observed band size: 152 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human Ron (aa10-60). The exact sequence is proprietary to MCE.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-200
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-200
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
1:50-200
IP
IP: Immunoprecipitation
1-2μg/sample
Sensitivity Endogenous 純度 affinity purified by Protein A
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand
Subcellular Localization：Membrane; Single-pass type I membrane protein
Expression：
Tissue_specificity:It is expressed in the colon, skin, lungs, and bone marrow.
Isoforms & Post-Translational Modification：Q04912 has 7 isomers: Q04912-1: 152241 Da (predicted); Q04912-2: 147247 Da (predicted); Q04912-3: 52519 Da (predicted); Q04912-4: 57721 Da (predicted); Q04912-5: 97315 Da (predicted); Q04912-6: 69265 Da (predicted); Q04912-7: 140697 Da (predicted).
Proteolytic processing yields the two subunits;Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site;Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation;O-mannosylation of IPT/TIG domains on Thr or Ser residues by TMEM260 is required for protein maturation (PubMed:37186866). O-mannosylated residues are composed of single mannose glycans that are not elongated or modified (PubMed:37186866)
Subunit：Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion
Synonyms
MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD antigen CD136
ドキュメンテーション
User Guide for Antibodies (1077 KB)

Ron Antibody (YA5046) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
Ron Antibody (YA5046)
製品番号:
HY-P85354
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