MST1R - macrophage stimulating 1 receptor Gene

Also Known as RON; SEA; PTK8; CD136; NPCA3; CDw136; p185-Ron

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4486

About MST1R

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,887,002-49,903,873 (from NCBI)

This gene has 13 transcripts (splice variants), 267 orthologues, 53 paralogues and is associated with 1 phenotype. Biased expression in skin (RPKM 17.5), stomach (RPKM 16.3) and 9 other tissues.

Summary

This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

MST1R Products (3)

mRNA	Protein	Name
NM_001244937.3	NP_001231866.1	macrophage-stimulating protein receptor isoform 2 precursor
NM_001318913.2	NP_001305842.1	macrophage-stimulating protein receptor isoform 3 precursor
NM_002447.4	NP_002438.2	macrophage-stimulating protein receptor isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	12676986	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15184888	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	12676986	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	12676986	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	12676986	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MST1R Protein Structure

Sema

TIG

Pkinase_Tyr

0
300
600
900
1200
1400 a.a.

Protein Preferred Names	Protein Names
macrophage-stimulating protein receptor	MSP receptor

MST1R Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MST1R	Q04912	PLXNB1	Homo sapiens	O43157	Anti Bait CoIP	15184888
Intra	MST1R	Q04912	PLXNB1	Homo sapiens	O43157	Anti Tag CoIP	15184888
Intra	MST1R	Q04912	PLXNB3	Homo sapiens	Q9ULL4	Anti Tag CoIP	15184888
Intra	MST1R	Q04912	PLXNB3	Homo sapiens	Q9ULL4	Anti Bait CoIP	15184888
Intra	MST1R	Q04912	MST1	Homo sapiens	P26927	SPR	22087277
Intra	MST1R	Q04912	MST1	Homo sapiens	P26927	Solution Sedimentation	25193665
Intra	MST1R	Q04912	PLXNB2	Homo sapiens	O15031	Anti Bait CoIP	15184888
Intra	MST1R	Q04912	PLXNB2	Homo sapiens	O15031	Anti Tag CoIP	15184888

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MST1R Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77180	RON/MSPR Protein, Human (HEK293, His, solution)	Q04912 (E25-L571)	≥ 95%, as determined by reducing SDS-PAGE.

MST1R Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810691	RON Antibody (YA9944)	WB, IHC-P, ICC/IF, IP, FC	Human
HY-P81384	RON Antibody (YA1129)	IHC-P	Human
HY-P81384A	RON Antibody (YA1129)(PBS only)	IHC-P	Human
HY-P84486	RON Antibody (YA4183)	WB, ELISA	Human
HY-P84486A	RON Antibody (YA4183)(PBS only)	WB, ELISA	Human
HY-P85354	Ron Antibody (YA5046)	WB, IHC-P, ICC/IF, IP, IF-Tissue	Human

Related Diseases

Diseases	Alias
Nasopharyngeal Carcinoma 3	NPCA3 Nasopharyngeal Carcinoma, Susceptibility To, 3 Nasopharyngeal Carcinoma, 3 {Nasopharyngeal Carcinoma, Susceptibility To, 3}
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Papillary Adenocarcinoma	Infiltrating And Papillary Adenocarcinoma Infiltrating Papillary Adenocarcinoma Adenocarcinoma Papillary Adenocarcinoma, Papillary
Pancreatic Adenocarcinoma	Adenocarcinoma Of The Pancreas Adenocarcinoma Of Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Familial Renal Papillary Carcinoma	Hereditary Papillary Renal Carcinoma Papillary Renal Cancer Hereditary
Arthrogryposis, Distal, Type 1c	DA1C Distal Arthrogryposis Type 1c Arthrogryposis, Distal, 1c
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly	Asphyxiating Thoracic Dystrophy 2 SRTD2 Atd2 Jatd Jeune Asphyxiating Thoracic Dystrophy Jeune Syndrome 2
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15514A	Merestinib dihydrochloride	Inhibitor	99.36%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15514	Merestinib	Inhibitor	99.99%	Yes
HY-RS08730	MST1R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18291	Mst1r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24769	Mst1r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991185	Anti-MST1R Antibody (MOR07692)	Inhibitor	99.44%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MST1R	VGNC	VGNC:68331
Macaca mulatta	MST1R	VGNC	VGNC:74941
Rattus norvegicus	MST1R	RGD	RGD:1306465
Canis familiaris	MST1R	VGNC	VGNC:43452
Mus musculus	MST1R	MGD	MGI:99614
Bos taurus	MST1R	VGNC	VGNC:31708
Others	MST1R	NCBI