RON Antibody (YA9944)
(Synonyms: MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD136)RON Antibody (YA1129) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RON.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, IP, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS(pH 7.4) containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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FC
FC: Flow Cytometry
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|---|---|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 | 1:30 | 1:50-100 |
Product Details
RON Antibody (YA1129) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RON.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 185 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 152 kDa
Recombinant protein of human RON
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH 7.4) containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RON is a Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand
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Subcellular Localization
Membrane
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Expression
Tissue_Specificity: Expressed in colon, skin, lung and bone marrow. -
Isoforms & Post-Translational Modification
RON has 7 isoforms, Q04912-1: amino acid length is 1400, molecular weight is 152241 Da (predicted); Q04912-2: amino acid length is 1351, molecular weight is 147247 Da (predicted); Q04912-3: amino acid length is 495, molecular weight is 52519 Da (predicted); Q04912-4: amino acid length is 541, molecular weight is 57721 Da (predicted); Q04912-5: amino acid length is 907, molecular weight is 97315 Da (predicted); Q04912-6: amino acid length is 647, molecular weight is 69265 Da (predicted); Q04912-7: amino acid length is 1294, molecular weight is 140697 Da (predicted).Proteolytic processing yields the two subunits
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Subunit
Heterodimer of an alpha chain and a beta chain which are disulfide linked.
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SwissProt ID
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Synonyms
MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD136
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Research Field
Cell Biology
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