PLXNB3 - plexin B3 Gene

Also Known as PLEXR; PLXN6; PLEXB3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5365

About PLXNB3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,764,249-153,779,341 (from NCBI)

This gene has 9 transcripts (splice variants), 172 orthologues and 8 paralogues. Broad expression in brain (RPKM 10.9), salivary gland (RPKM 4.4) and 16 other tissues.

Summary

The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

PLXNB3 Products (2)

mRNA Protein Name
NM_001163257.2 NP_001156729.1 plexin-B3 isoform 2
NM_005393.3 NP_005384.2 plexin-B3 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cell-cell adhesion mediator activity IPI
IPI: Inferred from physical interaction
16122393 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15184888 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
15218527 GOA
enables semaphorin receptor activity IDA
IDA: Inferred from direct assay
15218527 GOA
Biological Process GO Annotation Evidence References Source
involved in cell chemotaxis IDA
IDA: Inferred from direct assay
15218527 GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
16122393 GOA
involved in negative regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
20696765 GOA
involved in negative regulation of cell adhesion IDA
IDA: Inferred from direct assay
15218527 GOA
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20696765 GOA
involved in positive chemotaxis IDA
IDA: Inferred from direct assay
15218527 GOA
involved in positive regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19850054 GOA
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
16122393 GOA
involved in semaphorin-plexin signaling pathway IDA
IDA: Inferred from direct assay
15218527 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
16122393 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLXNB3 Protein Structure

Sema

Sema: Sema domain (55 - 428)

PSI

PSI: Plexin repeat (474 - 521)

TIG

TIG: IPT/TIG domain (835 - 924)

TIG

TIG: IPT/TIG domain (927 - 1011)

TIG

TIG: IPT/TIG domain (1165 - 1242)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1326 - 1876)

  • 0
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  • 1200
  • 1500
  • 1800
  • 1909 a.a.
Protein Preferred Names Protein Names

plexin-B3

  • plexin 6

PLXNB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLXNB3 Q9ULL4 FSCN1 Homo sapiens Q16658
Anti Bait CoIP
21706053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Glioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10754 PLXNB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29517 Plxnb3 Mouse Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PLXNB3 VGNC VGNC:68920
Canis familiaris PLXNB3 VGNC VGNC:44724
Mus musculus PLXNB3 MGD MGI:2154240
Rattus norvegicus PLXNB3 RGD RGD:1560615
Bos taurus PLXNB3 VGNC VGNC:33063
Macaca mulatta PLXNB3 VGNC VGNC:76189
Others PLXNB3 NCBI