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ROR1 Antibody (YA1486)

(Synonyms: ROR1; NTRKR1)
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ROR1 Antibody (YA1486) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROR1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4, 5 % trehalose is added as protectants

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:50-1:100 1:10000

Product Details

Description

ROR1 Antibody (YA1486) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROR1.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 50-70 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 101 kDa
Species Reactivity Database

Entrez Gene: 4919 Human

SwissProt: Q01973 Human

Immunogen

Recombinant human ROR1 protein

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3103847

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4, 5 % trehalose is added as protectants

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    ROR1 is a Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling[1][2][3].

  • Subcellular Localization

    Membrane; Single-pass type I membrane protein; Cell projection, axon

  • Expression


    Tissue_specificity:This gene is expressed strongly in the human heart, lungs, and kidneys, but weakly in the central nervous system. The short subtype is expressed strongly in the human central nervous system and in a variety of human cancers, including cancers originating from the neuroectoderm of the central or peripheral nervous system.

  • Isoforms & Post-Translational Modification

    Q01973 has 3 isomers: Q01973-1: 104283 Da (predicted); Q01973-2: 42833 Da (predicted); Q01973-3: 43826 Da (predicted).

  • Subunit

    Interacts with ERBB2 and IGFBP5

  • SwissProt ID

    Q01973

  • Gene ID
    4919 [NCBI]
  • Synonyms

    ROR1; NTRKR1

  • Research Field

    Signal Transduction

ROR1 Antibody (YA1486) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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