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  5. ROR1 Antibody (YA1486)

ROR1 Antibody (YA1486) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROR1.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

ROR1 Antibody (YA1486) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROR1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 101 kDa;
Observed band size: 50-70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Recombinant human ROR1 protein
Application &
Dilution Ratio
Application Dilution Ratio
FC
FC: Flow Cytometry
1:50-1:100
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:10000
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4, 5 % trehalose is added as protectants
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068)
Subcellular Localization：Membrane; Single-pass type I membrane protein; Cell projection, axon
Expression：
Tissue_specificity:This gene is expressed strongly in the human heart, lungs, and kidneys, but weakly in the central nervous system. The short subtype is expressed strongly in the human central nervous system and in a variety of human cancers, including cancers originating from the neuroectoderm of the central or peripheral nervous system.
Isoforms & Post-Translational Modification：Q01973 has 3 isomers: Q01973-1: 104283 Da (predicted); Q01973-2: 42833 Da (predicted); Q01973-3: 43826 Da (predicted).
Subunit：Interacts with ERBB2 and IGFBP5
RRID
Database

Entrez Gene: 4919 Human

SwissProt: Q01973 Human

OMIM: 617654 Human

Research Field

Signal Transduction
Synonyms
ROR1; NTRKR1
Documentation
SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

ROR1 Antibody (YA1486) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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ROR1 Antibody (YA1486)
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HY-P81741
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