SLC18A2 (VMAT2) Antibody (YA7778)(PBS only)
(Synonyms: SVAT; SVMT; VAT2; VMAT2)SLC18A2 (VMAT2) Antibody (YA7778) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC18A2 (VMAT2).
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:50-250 | 1:100-250 | 1:100 |
Product Details
SLC18A2 (VMAT2) Antibody (YA7778) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC18A2 (VMAT2).
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 55.7 kDa
Full-length protein expressed in 293T cell transfected with human SLC18A2 expression vector .
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SLC18A2 is an Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals. Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft. Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules[1][2][3][4][5][6].
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Subcellular Localization
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane,Cytoplasmic vesicle, secretory vesicle membrane,Cell projection, axon,Cell projection, dendrite
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Expression
Tissue_Specificity: Expressed in neuronal and neuroendocrine tissues. Detected in central and peripheral nervous system in particular in axonal and dendritic processes in dopaminergic cells of substantia nigra, histaminergic neuronal cell bodies of substantia nigra and tuberomammillary nucleus, in ganglion cells of sympathetic glia and in peripheral sympathetic nerve terminals in stomach and duodenum (at protein level). Highly expressed in chromaffin cells of the adrenal medulla and histamine-storing enterochromaffin-like cells of oxyntic mucosa (at protein level) -
Isoforms & Post-Translational Modification
Q05940 has two isomers: Q05940-1: 55713 Da (predicted); Q05940-2: 22980 Da (predicted).
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Subunit
Interacts with SLC6A3
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SwissProt ID
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Synonyms
SVAT; SVMT; VAT2; VMAT2
Documentation
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