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  5. SLC22A1/OCT1 Antibody (YA2426)

SLC22A1/OCT1 Antibody (YA2426)

Cat. No.: HY-P82681
User Guide for Antibodies Technical Support

SLC22A1/OCT1 Antibody (YA2426) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC22A1/OCT1.

For research use only. We do not sell to patients.

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20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

SLC22A1/OCT1 Antibody (YA2426) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC22A1/OCT1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 61 kDa;
Observed band size: 72 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human SLC22A1 aa100-150/554.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
FC
FC: Flow Cytometry
1:50-1:100
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:11388889, PubMed:11408531, PubMed:12439218, PubMed:12719534, PubMed:15389554, PubMed:16263091, PubMed:16272756, PubMed:16581093, PubMed:19536068, PubMed:21128598, PubMed:23680637, PubMed:24961373, PubMed:34040533, PubMed:9187257, PubMed:9260930, PubMed:9655880). Functions as a pH- and Na(+)-independent, bidirectional transporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (By similarity). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (By similarity). Primarily expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (By similarity). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal elimination of organic cations from the systemic circulation (PubMed:16263091). Transports endogenous monoamines such as N-1-methylnicotinamide (NMN), guanidine, histamine, neurotransmitters dopamine, serotonin and adrenaline (PubMed:12439218, PubMed:24961373, PubMed:35469921, PubMed:9260930). Also transports natural polyamines such as spermidine, agmatine and putrescine at low affinity, but relatively high turnover (PubMed:21128598). Involved in the hepatic uptake of vitamin B1/thiamine, hence regulating hepatic lipid and energy metabolism (PubMed:24961373). Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium (PubMed:15817714). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with lower efficency (PubMed:17460754). Also capable of transporting non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (PubMed:11907186). May contribute to the transport of cationic compounds in testes across the blood-testis-barrier (Probable). Also involved in the uptake of xenobiotics tributylmethylammonium (TBuMA), quinidine, N-methyl-quinine (NMQ), N-methyl-quinidine (NMQD) N-(4,4-azo-n-pentyl)-quinuclidine (APQ), azidoprocainamide methoiodide (AMP), N-(4,4-azo-n-pentyl)-21-deoxyajmalinium (APDA) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (PubMed:11408531, PubMed:15389554, PubMed:35469921, PubMed:9260930); Mediates the uptake of 1-methyl-4-phenylpyridinium (MPP(+)); Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+)); Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+)); Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+))
Subcellular Localization：Basolateral cell membrane; Multi-pass membrane protein; Apical cell membrane; Multi-pass membrane protein; Lateral cell membrane; Multi-pass membrane protein; Basal cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein
Expression：
Tissue_specificity:It is widely expressed in the liver at high levels (PubMed:11388889, PubMed:23680637, PubMed:9187257, PubMed:9260930) . In the liver, it is mainly expressed around the central vein (PubMed:16263091) . It is also expressed in the kidneys (PubMed:9187257, PubMed:9260930) . It is also expressed in enterocytes of the small intestine (PubMed:16263091, PubMed:23680637) . In the testes, it is mainly located in peritubular myoid cells and Leydig cells, and moderately expressed in the basement membrane of Sertoli cells (PubMed:35307651) . It is also expressed in the ciliated epithelium of the trachea and bronchi in the respiratory tract (PubMed:15817714) . It is also expressed in skeletal muscle, stomach, spleen, heart, placenta, colon, brain, granulocytes, and lymphocytes (PubMed:9187257, PubMed:9260930) ; expressed in the liver and glial cell lines; expressed in the liver and glial cell lines; expressed in glial cell lines. Not expressed in the liver; expressed in glial cell lines. Not expressed in the liver.

Induction:In the liver activated by HNF4A and suppressed by bile acids via NR0B2. Increased by cholesterol treatment in hepatocyte cells
Isoforms & Post-Translational Modification：O15245 has 4 isomers: O15245-1: 61154 Da (predicted); O15245-2: 56094 Da (predicted); O15245-3: 53593 Da (predicted); O15245-4: 39224 Da (predicted).
Phosphorylated
Database

Entrez Gene: 6580 Human

SwissProt: O15245 Human

OMIM: 602607 Human

Research Field

-
Synonyms
hOCT1; OCT1; Slc22a1
Documentation
User Guide for Antibodies (1077 KB)

SLC22A1/OCT1 Antibody (YA2426) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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