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SOX10 Antibody (YA5918)

(Synonyms: DOM; WS4; PCWH; WS2E; WS4C; SOX-10)
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Based on 1 Customer Validation

SOX10 Antibody (YA5918) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOX10.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG/Kappa

  • Application:

    WB, IHC-P, ICC/IF, IP, ELISA

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for SOX10 Antibody (YA5918)
  • SOX10 Antibody (YA5918) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:1000-1:4000 1:2000-1:10000 1:200-1:1000 1:5000-1:20000 1:50-1:200

Product Details

Description

SOX10 Antibody (YA5918) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOX10.

  • Host Rabbit
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 62 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 50 kDa
Purification

Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG/Kappa

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for SOX10 Antibody (YA5918)
    Western blot analysis of extracts from Hela (lane 2, 20ug), HT-29 (lane3, 20μg) and Rat brain tissue (lane4, 20μg) using SOX10 Antibody (HY-P86226). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/2000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (HY-P8001,1/10,000) was used for 1 hour at room temperature.

Background

  • Function

    SOX10 transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter[1].

  • Subcellular Localization

    Cytoplasm; Nucleus; Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side

  • Expression


    Tissue_specificity:It is expressed in the fetal brain, as well as in the human brain, heart, small intestine, and colon.

  • Isoforms & Post-Translational Modification

    P56693 has 2 isomers: P56693-1: 49911 Da (predicted); P56693-2: 31088 Da (predicted).

  • Subunit

    Monomer. Interacts with ARMCX3 at the mitochondrial outer membrane surface. Interacts with PAX3 (PubMed:21965087)

  • SwissProt ID

    P56693

  • Gene ID
    6663 [NCBI]
  • Synonyms

    DOM; WS4; PCWH; WS2E; WS4C; SOX-10

SOX10 Antibody (YA5918) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from Hela (lane 2, 20ug), HT-29 (lane3, 20μg) and Rat brain tissue (lane4, 20μg) using SOX10 Antibody (HY-P86226). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/2000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (HY-P8001,1/10,000) was used for 1 hour at room temperature.

  • SOX10 Antibody (YA5918) Product Image
    1/16
  • Experimental Validation Results for SOX10 Antibody (YA5918)
  • SOX10 Antibody (YA5918) Product Image
  • Experimental Validation Results for SOX10 Antibody (YA5918)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from Hela (lane 2, 20ug), HT-29 (lane3, 20μg) and Rat brain tissue (lane4, 20μg) using SOX10 Antibody (HY-P86226). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/2000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (HY-P8001,1/10,000) was used for 1 hour at room temperature.
  • Experimental Validation Results for SOX10 Antibody (YA5918)
  • SOX10 Antibody (YA5918) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from Hela (lane 2, 20ug), HT-29 (lane3, 20μg) and Rat brain tissue (lane4, 20μg) using SOX10 Antibody (HY-P86226). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/2000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (HY-P8001,1/10,000) was used for 1 hour at room temperature.

  • SOX10 Antibody (YA5918) Product Image WB