Surfeit Locus Protein 4 Antibody (YA2465)(PBS only)

Art. -Nr.: HY-P82720A: Data Sheet User Guide for Antibodies
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Surfeit Locus Protein 4 Antibody (YA2465) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Surfeit Locus Protein 4.

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100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung

Beschreibung

Surfeit Locus Protein 4 Antibody (YA2465) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Surfeit Locus Protein 4.

Host

Rabbit

Molekulargewicht

Predicted band size: 30 kDa;

Observed band size: 30 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O15260

Gene ID

6836 [NCBI]

Immunogen

A synthetic peptide of human SURF4 aa:144-157.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200

Reinheit	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:29643117, PubMed:30251625, PubMed:33186557). Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:29643117, PubMed:33186557). Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins (PubMed:33186557). Promotes the secretion of PCSK9 (PubMed:30251625). Also mediates the efficient secretion of erythropoietin (EPO) (PubMed:32989016). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (PubMed:18287528)

Subcellular Localization：Endoplasmic reticulum membrane; Multi-pass membrane protein; Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein; Golgi apparatus membrane; Multi-pass membrane protein

Isoforms & Post-Translational Modification：O15260 has 3 isomers: O15260-1: 30394 Da (predicted); O15260-2: 17970 Da (predicted); O15260-3: 14854 Da (predicted).

Subunit：Found in a complex composed at least of SURF4, TMED2 and TMED10 (PubMed:18287528). May interact with LMAN1 (PubMed:18287528). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts with STING1 (PubMed:29251827). Interacts with SAR1B (PubMed:33186557). Interacts with TMEM41B (PubMed:34015269)

Research Field

Tags & Cell Markers

Synonyms

ERV29

Dokumentation

User Guide for Antibodies (1077 KB)