SURF4 - surfeit 4 Gene

Also Known as ERV29

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6836

About SURF4

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:133,361,464-133,377,949 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 252 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 40.0), small intestine (RPKM 39.7) and 25 other tissues.

Summary

This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

SURF4 Products (7)

mRNA	Protein	Name
NM_001280788.2	NP_001267717.1	surfeit locus protein 4 isoform 2
NM_001280789.2	NP_001267718.1	surfeit locus protein 4 isoform 3
NM_001280790.2	NP_001267719.1	surfeit locus protein 4 isoform 4
NM_001280791.2	NP_001267720.1	surfeit locus protein 4 isoform 4
NM_001280792.2	NP_001267721.1	surfeit locus protein 4 isoform 5
NM_001280793.2	NP_001267722.1	surfeit locus protein 4 isoform 6
NM_033161.4	NP_149351.1	surfeit locus protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables COPII receptor activity	IDA IDA: Inferred from direct assay	33186557	GOA
enables cargo receptor activity	IDA IDA: Inferred from direct assay	30251625	GOA
enables cargo receptor activity	IMP IMP: Inferred from mutant phenotype	29643117	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18287528	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	18287528	GOA
NOT involved in early endosome to Golgi transport	IMP IMP: Inferred from mutant phenotype	18287528	GOA
involved in lipid homeostasis	IDA IDA: Inferred from direct assay	34015269	GOA
involved in lipoprotein transport	IDA IDA: Inferred from direct assay	34015269	GOA
involved in lipoprotein transport	IMP IMP: Inferred from mutant phenotype	29643117	GOA
involved in positive regulation of organelle organization	IMP IMP: Inferred from mutant phenotype	18287528	GOA
NOT involved in protein exit from endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	18287528	GOA
involved in regulation of lipid transport	IDA IDA: Inferred from direct assay	34015269	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in COPII-coated ER to Golgi transport vesicle	IDA IDA: Inferred from direct assay	33186557	GOA
is active in endoplasmic reticulum exit site	IDA IDA: Inferred from direct assay	33186557	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SURF4 Protein Structure

SURF4

0
100
200
269 a.a.

Protein Preferred Names	Protein Names
surfeit locus protein 4	surface 4 integral membrane protein

SURF4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SURF4	O15260	LMAN1	Homo sapiens	P49257	Anti Bait CoIP	18287528
Intra	SURF4	O15260	LMAN1	Homo sapiens	P49257	Confocal	18287528
Intra	SURF4	O15260	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

SURF4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82720	Surfeit Locus Protein 4 Antibody (YA2465)	WB, ICC/IF	Human, Mouse, Rat
HY-P82720A	Surfeit Locus Protein 4 Antibody (YA2465)(PBS only)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Colorectal Cancer, Hereditary Nonpolyposis, Type 2	HNPCC2 Fcc2 Coca2 Hereditary Nonpolyposis Colorectal Cancer Type 2 Colon Cancer, Familial Nonpolyposis, Type 2 Familial Nonpolyposis Colon Cancer Type 2 Hereditary Non-Polyposis Colorectal Cancer 2 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2
Macular Degeneration, Age-Related, 4	Age Related Macular Degeneration 4 ARMD4 Macular Degeneration, Age-Related, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14044	SURF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SURF4	VGNC	VGNC:106962
Rattus norvegicus	SURF4	RGD	RGD:1561980
Felis catus	SURF4	VGNC	VGNC:102990
Canis familiaris	SURF4	VGNC	VGNC:46996
Mus musculus	SURF4	MGD	MGI:98445
Macaca mulatta	SURF4	VGNC	VGNC:78060
Others	SURF4	NCBI