Surfeit Locus Protein 4 Antibody (YA2465)
(Synonyms: ERV29)Surfeit Locus Protein 4 Antibody (YA2465) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Surfeit Locus Protein 4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:200 |
Product Details
Surfeit Locus Protein 4 Antibody (YA2465) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Surfeit Locus Protein 4.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 30 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 30 kDa
Entrez Gene: 6836 Human ; 20932 Mouse ; 619346 Rat
SwissProt: O15260 Human ; Q64310 Mouse ;
OMIM: 185660 Human
A synthetic peptide of human SURF4 aa:144-157.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Surfeit Locus Protein 4 is an Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins. Promotes the secretion of PCSK9. Also mediates the efficient secretion of erythropoietin (EPO). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi[1][2][3][4][5].
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Subcellular Localization
Endoplasmic reticulum membrane; Multi-pass membrane protein; Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein; Golgi apparatus membrane; Multi-pass membrane protein
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Isoforms & Post-Translational Modification
O15260 has 3 isomers: O15260-1: 30394 Da (predicted); O15260-2: 17970 Da (predicted); O15260-3: 14854 Da (predicted).
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Subunit
Found in a complex composed at least of SURF4, TMED2 and TMED10 (PubMed:18287528). May interact with LMAN1 (PubMed:18287528). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts with STING1 (PubMed:29251827). Interacts with SAR1B (PubMed:33186557). Interacts with TMEM41B (PubMed:34015269)
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SwissProt ID
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Synonyms
ERV29
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Research Field
Tags & Cell Markers
Documentation
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