Copy Link Print Information

TIPRL Antibody (YA7848)(PBS only)

(Synonyms: TIP; TIP41)

TIPRL Antibody (YA7848) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TIPRL.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • TIPRL Antibody (YA7848)(PBS only) Product Image
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Service
Data Download
Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
FC Info
FC: Flow Cytometry
Dilution Ratio 1:500-2000 1:100

Product Details

Description

TIPRL Antibody (YA7848) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TIPRL.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 31.4 kDa
Immunogen

Full length human recombinant protein of human TIPRL produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TIPRL may be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair

  • Subcellular Localization

    Cytoplasm

  • Isoforms & Post-Translational Modification

    O75663 has two isomers: O75663-1: 31444 Da (predicted); O75663-2: 20214 Da (predicted).

  • Subunit

    Isoform 1 interacts with PPP2CA

  • SwissProt ID

    O75663

  • Synonyms

    TIP; TIP41

TIPRL Antibody (YA7848)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • TIPRL Antibody (YA7848)(PBS only) Product Image
    1/16
  • TIPRL Antibody (YA7848)(PBS only) Product Image