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Cat. No.: HY-P86274

Transmembrane Protein 192 Antibody (YA5966)

Name: Transmembrane Protein 192 Antibody (YA5966)
Brand: MedChemExpress
SKU: HY-P86274
Availability: PreOrder

(Synonyms: TMEM192; Transmembrane protein 192; )

Transmembrane Protein 192 Antibody (YA5966) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 192.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	FC 1
Dilution Ratio	1:1000-5000	100-300

Description

Transmembrane Protein 192 Antibody (YA5966) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 192.

Host Rabbit
Clonality Monoclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 30 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Purification

Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Solution
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

Transmembrane protein 192 (TMEM192) is a lysosomal/late endosomal membrane protein containing four transmembrane segments. It exists as a homodimer, with an N-terminal dileucine motif mediating lysosomal targeting and a C-terminal cysteine motif mediating disulfide bond formation. It is widely expressed throughout the body, but is significantly overexpressed in tumor cells. Functionally, TMEM192 is involved in maintaining lysosomal membrane integrity and acidification, regulating autophagy-apoptosis crosstalk (liver cancer cells), mediating retinoic acid-induced autophagy along the TIG1-TMEM192 axis (cervical cancer), and is a key molecule in lysosomal autophagy. TMEM192 plays an important role under stress conditions such as tumor and lysosomal damage.
Subcellular Localization

Lysosome membrane; Multi-pass membrane protein; Late endosome
Expression

Tissue_specificity:It is highly expressed in the kidneys, liver, lungs, and pancreas.
Isoforms & Post-Translational Modification

Q8IY95 has 2 isomers: Q8IY95-1: 30922 Da (predicted); Q8IY95-2: 30549 Da (predicted).
Not N-glycosylated
Subunit

Homodimer
SwissProt ID

Q8IY95
Gene ID

201931 [NCBI]
Synonyms

TMEM192; Transmembrane protein 192;