TTLL12 Antibody (YA8123)(PBS only)

Cat. No.: HY-P88439A: Data Sheet User Guide for Antibodies
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TTLL12 Antibody (YA8123) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TTLL12.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

TTLL12 Antibody (YA8123) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TTLL12.

Host

Mouse

Molecular Weight

Predicted band size: 74.4 kDa

Species Reactivity

Human, Dog, Mouse, Rat

SwissProt ID

Q14166

Immunogen

Full length human recombinant protein of human TTLL12 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935)

Subcellular Localization：Cytoplasm,Midbody,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,Cytoplasm, cytoskeleton, spindle,Nucleus

Expression：
Tissue_Specificity: Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions

Isoforms & Post-Translational Modification：Q14166: 644 amino acids, molecular weight 74404 Da.

Subunit：Interacts with MAVS; the interaction prevents MAVS binding to TBK1 and IKBKE (PubMed:28011935)

Synonyms

dJ526I14.2

Documentation

User Guide for Antibodies (1077 KB)