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WWTR1 (TAZ) Antibody (YA7748)(PBS only)

(Synonyms: TAZ)

WWTR1 (TAZ) Antibody (YA7748) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to WWTR1 (TAZ).

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    WB, ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • WWTR1 (TAZ) Antibody (YA7748)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:500-2000 1:100-250 1:100

Product Details

Description

WWTR1 (TAZ) Antibody (YA7748) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to WWTR1 (TAZ).

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 43.9 kDa
Immunogen

Full length human recombinant protein of human WWTR1 produced in HEK293 cell.

Sensitivity

Endogenous

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    WWTR1 transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition[1][2][3][4][5].

  • Subcellular Localization

    Nucleus,Cytoplasm,Cell membrane,Cell junction, tight junction

  • Expression


    Tissue_Specificity: Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue

  • Isoforms & Post-Translational Modification

    Q9GZV5: 400 amino acids, molecular weight 44101 Da.

  • Subunit

    Binds to SLC9A3R2 via the PDZ motif at the plasma membrane (By similarity)

  • SwissProt ID

    Q9GZV5

  • Synonyms

    TAZ

WWTR1 (TAZ) Antibody (YA7748)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • WWTR1 (TAZ) Antibody (YA7748)(PBS only) Product Image
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  • WWTR1 (TAZ) Antibody (YA7748)(PBS only) Product Image