2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 104

Anticancer agent 104 has anticancer activity, and induces cancer cell apoptosis.

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Anticancer agent 104

Anticancer agent 104 Chemical Structure

CAS No. : 3047612-51-8

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Anticancer agent 104 Related Antibodies

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Description

Anticancer agent 104 has anticancer activity, and induces cancer cell apoptosis[1].

Cellular Effect
Cell Line Type Value Description References
786-0 IC50
91.67 μM
Compound: 4l
Anticancer activity against human 786-0 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human 786-0 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37084600]
Calu-1 IC50
78.34 μM
Compound: 4l
Anticancer activity against human Calu-1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human Calu-1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37084600]
HEK-293T IC50
195.17 μM
Compound: 4l
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37084600]
HepG2 IC50
31.39 μM
Compound: 4l
Anticancer activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37084600]
Huh-7 IC50
75.18 μM
Compound: 4l
Anticancer activity against human Huh-7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human Huh-7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37084600]
KGN IC50
176.38 μM
Compound: 4l
Cytotoxicity against human KGN cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human KGN cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37084600]
LX-2 IC50
96.33 μM
Compound: 4l
Cytotoxicity against human LX2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human LX2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37084600]
MCF-10A IC50
21.06 μM
Compound: 4l
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37084600]
SK-BR-3 IC50
44.18 μM
Compound: 4l
Anticancer activity against human SK-BR-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human SK-BR-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37084600]
SK-OV-3 IC50
112.19 μM
Compound: 4l
Anticancer activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37084600]
WI-38 IC50
81.48 μM
Compound: 4l
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37084600]
In Vitro

Anticancer agent 104 (Compound 4l) (48 h) is toxic to HepG2 cells (IC50: 31.39 μM)[1].
Anticancer agent 104 (10-200 μg/mL, 48 h) exhibits volume reduction, chromatin margination, and eventually formed apoptotic vesicles[1].
Anticancer agent 104 (10-100 μg/mL, 48 h) induces HepG2 cell apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 104 Related Antibodies

Western Blot Analysis[1]

Cell Line: Calu-1, SK-BR-3, HUH-7, 786-O, SK-OV-3 cells
Concentration: 0-200 μM approximately
Incubation Time: 48 h
Result: Shows cytotoxic activities with IC50s of 78.34, 44.18, 75.18, 91.67, 112.19 μM.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 10, 50 and 100 μg/mL
Incubation Time: 48 h
Result: Showed apoptotic rate of 23.67%, 41.21% and 61.16% respectively.
Molecular Weight

636.87

Formula

C34H47F3N2O2S2
CAS No.
SMILES

C[C@@]1(C(C)([C@@](CC1)([H])C2)C)[C@@H]2OC(CCC[C@@H]3[C@]4([H])[C@]5([H])[C@](CCCN5CCC4)([H])CN3C(SCC6=CC=C(C=C6)C(F)(F)F)=S)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 104 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 1043047612-51-8Anticancer agent104Anticancer agent-104ApoptosisHepG2cancerInhibitorinhibitorinhibit

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