AR03
Based on 1 Customer Validation
AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells.
For research use only. We do not sell to patients.
- Purity: 99.1%
- CAS No.: 510721-85-4
- Formula: C15H15N3
- Molecular Weight:237.30
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 2.1 µM (Ape1)[1]
Chemical Information
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CAS No. 510721-85-4
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Appearance Solid
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Molecular Weight 237.30
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Formula C15H15N3
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Color Light yellow to yellow
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SMILES
CC1=C2N=C3N=C(C=C(C3=C(C2=CC=C1)N)C)C
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Synonyms
BMH-23
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 24.1 mg/mL (101.56 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2141 mL | 21.0704 mL | 42.1407 mL | 105.3519 mL |
| 5 mM | 0.8428 mL | 4.2141 mL | 8.4281 mL | 21.0704 mL | |
| 10 mM | 0.4214 mL | 2.1070 mL | 4.2141 mL | 10.5352 mL | |
| 15 mM | 0.2809 mL | 1.4047 mL | 2.8094 mL | 7.0235 mL | |
| 20 mM | 0.2107 mL | 1.0535 mL | 2.1070 mL | 5.2676 mL | |
| 25 mM | 0.1686 mL | 0.8428 mL | 1.6856 mL | 4.2141 mL | |
| 30 mM | 0.1405 mL | 0.7023 mL | 1.4047 mL | 3.5117 mL | |
| 40 mM | 0.1054 mL | 0.5268 mL | 1.0535 mL | 2.6338 mL | |
| 50 mM | 0.0843 mL | 0.4214 mL | 0.8428 mL | 2.1070 mL | |
| 60 mM | 0.0702 mL | 0.3512 mL | 0.7023 mL | 1.7559 mL | |
| 80 mM | 0.0527 mL | 0.2634 mL | 0.5268 mL | 1.3169 mL | |
| 100 mM | 0.0421 mL | 0.2107 mL | 0.4214 mL | 1.0535 mL |
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