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Art. -Nr.: HY-169429

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CHIKV-IN-5

CHIKV-IN-5 (Compound 26) is a CHIKV inhibitor (EC₉₀ = 0.45 μM). CHIKV-IN-5 inhibits CHIKV replication at a late stage in the virus life cycle by blocking structural protein translation. CHIKV-IN-5 has great in vitro mouse microsomal stability. CHIKV-IN-5 reduces footpad swelling and decreases virus dissemination to other tissues in mice infected with CHIKV.

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CAS. Nr.: 2568903-91-1
Formel: C₂₃H₁₇N₅OS₂
Molecular Weight:443.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

CHIKV-IN-5 Chemical Structure

CAS. Nr.: 2568903-91-1

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

CHIKV-IN-5 shows good virus titer reduction (VTR = 8.7 log at 10 μM concentration) in normal human dermal fibroblast cells and in vitro mouse microsomal stability (MLM_t1/2=74 min)^[1].
CHIKV-IN-5 (10 μM, 2 h) blocks CHIKV replication post-entry on NHDF cells^[1].
CHIKV-IN-5 (10 μM, pretreats for 1 h) inhibits CHIKV structural protein synthesis but not viral transcription in CHIKV infected NHDF cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CHIKV-IN-5 (80 mg/kg, i.p., twice a day, 3 days) reduces footpad swelling and significantly decrease virus dissemination to other tissues in CHIKV-infected mice ^[1].
CHIKV-IN-5 (0.5-20 mg/kg, i.p., i.v., p.o., s.c.) shows favorable metabolic stability in male C57BL/6 mice ^[1].
Pharmacokinetic (PK) analysis in mice (CHIKV-IN-5)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CHIKV-infected male C57BL/6 mice (1000 PFU CHIKV_181/25 in a 20 μL volume)^[1]
Dosage:

80 mg/kg
Administration:

Intraperitoneal injection (i.p.), twice a day, 3 days
Result:

Reduced footpad swelling as a result of infection.
Significant reduction in secondary tissue spread to the spleen and right quadriceps tissues was detected.

Animal Model:

Male C57BL/6 mice^[1]
Dosage:

i.v.:0.5 mg/mL, p.o., s.c., i.p.: 20 mg/mL
Administration:

Intravenous (i.v.), Intraperitoneal (i.p.), Oral (p.o.), Subcutaneous (s.c.)
Result:

Displayed good parameters by the i.p. route with the longest t1/2 time (3.52 h), highest concentration (2460 ng/mL) and greatest bioavailability (91%).

Chemical Information

CAS. Nr. 2568903-91-1
Molecular Weight 443.54
Formel C₂₃H₁₇N₅OS₂
SMILES

O=C(NC1=NC(C2=CC(NC3=CC=C(C=C3)C#N)=CC=C2)=CS1)C4=C(N=CC=C4)SC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Garzan, et al. 4-Substituted-2-Thiazole Amides as Viral Replication Inhibitors of Alphaviruses. Journal of medicinal chemistry. 2024, 67(23), 20858–20878. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

parameters	i.v.	i.p.	p.o.	s.c.
t_1/2 (h)	1.78	3.52	2.38	5.70
AUC (h × ng/mL)	821	30648	15292	1524
C_max (ng/mL)	-	2460	2100	142
%F	-	91	45	5

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