FtsZ-IN-6
FtsZ-IN-6 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-6 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-6 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-6 shows low hemolytic activity and cytotoxicity to mammalian cells.
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- Formel: C28H22BrN3O2
- Molecular Weight:512.40
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
FtsZ-IN-6 (compound B6) inhibits the tested Gram-positive bacteria including methicillin-resistant S. aureus (MRSA) (MIC=0.098 μg/mL), B. subtilis (MIC=0.098 μg/mL) and S. pneumoniae (MIC=0.049 μg/mL)[1].
FtsZ-IN-6 (1-4× MIC; 0-24 h) inhibits bacterial grwoth. And FtsZ-IN-6 (4× MIC; 4 h) disturbs the cell surface of MRSA ATCC43300, with notable wrinkling and filamentation on their surfaces[1].
FtsZ-IN-6 (4 μg/mL; 10 min; 25 °C) promotes FtsZ polymerization and (0.02-0.64 μg/mL; 30 min) inhibits the GTPase activity of FtsZ dose-dependently[1].
FtsZ-IN-6 (12.5 μg/mL; 1 h; 37 °C) revealing the negligible hemolytic activity against human erythrocytes RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MRSA ATCC43300
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Concentration:1 × , 2 × , 4 × MIC; MIC=0.098 μg/mL
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Incubation Time:0 h, 0.5 h, 1 h, 1.5 h, 2 h, 4 h, 6 h, 8 h, 12 h, 22 h, and 24 h
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Result:Inhibited the growth of bacteria, and more fast compared with Vancomycin (HY-B0671).
Chemical Information
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Molecular Weight 512.40
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Formel C28H22BrN3O2
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SMILES
CC(C1=CC=CC(NC(C2=CC3=C(NC4=C3C=C[N+]5=C4C(C6=C5C=CC=C6)=O)C=C2)=O)=C1)C.[Br-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
FtsZ-IN-6 Related Classifications
HY-149224 Related Classifications
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