Galacto-PUGNAc
Galacto-PUGNAc is a selective competitive inhibitor of lysosomal β-hexosaminidases (HEX), with Ki values of 51 and 18 nM, for hHEXA and hHEXB, respectively. Galacto-PUGNAc elevates GM2 ganglioside levels in neuroblastoma cells. Galacto-PUGNAc can be used for the research of neurodegenerative disorders.
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- CAS. Nr.: 1145878-98-3
- Formel: C15H19N3O7
- Molecular Weight:353.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
Galacto-PUGNAc inhibits purified G. gallus GH 27 α-N-acetylgalactosaminidase with a Ki of 140 mM, showing 2800-fold selectivity for human lysosomal β-hexosaminidases[1].
Galacto-PUGNAc (200 μM; 9 days) increases GM2 ganglioside levels by 30-40% in human SK-N-SH neuroblastoma cells[1].
Galacto-PUGNAc (50 μM; overnight) does not increase O-GlcNAc-modified protein levels in cultured human SK-N-SH neuroblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1145878-98-3
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Molecular Weight 353.33
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Formel C15H19N3O7
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SMILES
O[C@@H]([C@@H](CO)O/1)[C@H](O)[C@@H](NC(C)=O)C1=N\OC(NC2=CC=CC=C2)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Galacto-PUGNAc Related Classifications
HY-108241A Related Classifications
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