ITK - IL2 inducible T cell kinase Gene

Also Known as EMT; LYK; LPFS1; PSCTK2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3702

About ITK

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:157,180,840-157,255,185 (from NCBI)

This gene has 11 transcripts (splice variants), 206 orthologues, 32 paralogues and is associated with 69 phenotypes. Biased expression in lymph node (RPKM 23.9), appendix (RPKM 14.7) and 9 other tissues.

Summary

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

ITK Products (1)

mRNA	Protein	Name
NM_005546.4	NP_005537.3	tyrosine-protein kinase ITK/TSK

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	12186560	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8892607	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITK Protein Structure

BTK

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
500
620 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase ITK/TSK	IL-2-inducible T-cell kinase T-cell-specific kinase homolog of mouse T-cell itk/tsk interleukin-2-inducible T-cell kinase kinase EMT tyrosine-protein kinase LYK

ITK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ITK	Q08881	LCP2	Homo sapiens	Q13094	Anti Tag CoIP	17420479
Intra	ITK	Q08881	LCP2	Homo sapiens	Q13094	Anti Bait CoIP	17420479
Intra	ITK	Q08881	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	ITK	Q08881	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	28514442
Intra	ITK	Q08881	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	ITK	Q08881	SFN	Homo sapiens	P31947	Pull Down	32707033
Intra	ITK	Q08881	FASLG	Homo sapiens	P48023	Pull Down	19807924
Intra	ITK	Q08881	FASLG	Homo sapiens	P48023	Phage Display	19807924
Intra	ITK	Q08881	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Cross	ITK	Q08881	Plcg1	Rattus norvegicus	P10686	Protein Kinase Assay	18443296
Cross	ITK	Q08881	Plcg1	Rattus norvegicus	P10686	Pull Down	31585087

Cross: Cross-species interaction Intra: Intraspecies interaction

ITK Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83601	ITK Antibody (YA3346)	WB, IHC-P, FC	Human
HY-P83601A	ITK Antibody (YA3346)(PBS only)	WB, IHC-P, FC	Human
HY-P85135	ITK Antibody (YA4827)	WB, ICC/IF, FC, ELISA	Human
HY-P85135A	ITK Antibody (YA4827)(PBS only)	WB, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Hemophagocytic Lymphohistiocytosis	Lymphohistiocytosis, Hemophagocytic Haemophagocytic Syndrome Lymphohistiocytosis Hemophagocytic Hemophagocytic Syndrome Familial Hemophagocytic Lymphocytosis Histiocytoses Of Mononuclear Phagocytes Haemophagocytic Lymphohistiocytosis Nos
Lymphopenia	Lymphocytopenia
Conjunctival Deposit
Supine Hypotensive Syndrome	Maternal Hypotension Syndrome Antepartum Maternal Hypotension Syndrome Postpartum Maternal Hypotension Syndrome Maternal Hypotension Syndrome, Antepartum Condition Or Complication Maternal Hypotension Syndrome, Postpartum Condition Or Complication Maternal Hypotension Syndrome, Unspecified Trimester
Coronin-1a Deficiency
Angioimmunoblastic T-Cell Lymphoma	Immunoblastic Lymphadenopathy Lymphogranulomatosis X T-Cell Lymphoma, Aild Type Aitl Ailt Angioimmunoblastic Lymphadenopathy Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia] Angioimmunoblastic Lymphoma
Lissencephaly 10	LIS10
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp XLP1 Lyp X-Linked Lymphoproliferative Disease Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Lymphoproliferative Syndrome 2	Cd27 Deficiency LPFS2 Combined Immunodeficiency Due To Cd27 Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Agammaglobulinemia, X-Linked	X-Linked Agammaglobulinemia XLA Bruton Type Agammaglobulinemia Bruton'S Agammaglobulinemia Bruton-Type Agammaglobulinemia Agmx1 Imd1 Agammaglobulinemia, X-Linked 1 Btk-Deficiency Agammaglobulinemia Hypogammaglobulinemia Agammaglobulinemia, X-Linked, Type 1 Immunodeficiency 1 Bruton Agammaglobulinemia Tyrosine Kinase Deficiency Bruton'S Agammaglobulinaemia Bruton'S Sex-Linked Agammaglobulinemia Bruton'S Type Agammaglobulinemia Btk Deficiency Agammaglobulinemia, Btk Agammaglobulinemia, Bruton Tyrosine Kinase Congenital Agammaglobulinemia Immunodeficiency Type 1 X-Linked Agammaglobulinemia Type 1
Lymphoproliferative Syndrome, X-Linked, 2	XLP2 Xiap Deficiency X-Linked Lymphoproliferative Syndrome 2 X-Linked Lymphoproliferative Disease Due To Xiap Deficiency Xiap-Related Lymphoproliferative Disease, X-Linked X-Linked Lymphoproliferative Syndrome Type 2 Xiap Deficiency Syndrome
B Cell Deficiency	Immunoglobulin Heavy Chain Deficiency B Cell Deficiencies Immunoglobulin Heavy Chain Deletion Humoral Immune Defect
Pancytopenia
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	XMEN X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia Cid Due To Magt1 Deficiency Combined Immunodeficiency Due To Magt1 Deficiency X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia
Lissencephaly 7 With Cerebellar Hypoplasia	LIS7 Lissencephaly 7, With Cerebellar Hypoplasia Lissencephaly, Type 7, With Cerebellar Hypoplasia
Waldenstroem'S Macroglobulinemia	Waldenstrom Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstrom'S Macroglobulinaemia Waldenstrom'S Syndrome Waldenström Macroglobulinemia Waldenstrom'S Macroglobulinemia Wm Waldenström'S Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev
Mixed Oligodendroglioma-Astrocytoma	Who Grade Ii Mixed Glioma
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Lymphoproliferative Syndrome 1	LPFS1 Lymphoproliferative Syndrome, Ebv-Associated, Autosomal, 1 Combined Immunodeficiency Due To Itk Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Itk Deficiency Itk Deficiency
Immunodeficiency 17	IMD17 Cd3-Gamma Deficiency Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive Combined Immunodeficiency Due To Cd3gamma Deficiency Immunodeficiency 17, Cd3 Gamma Deficient Cd3gamma Deficiency Immunodeficiency, Type 17

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-150298	Soquelitinib	Inhibitor	99.98%	Phase 3
HY-109078	Vecabrutinib	Inhibitor	99.76%	Phase 2

Pre-clinical Phase

Bioactive Molecules (27)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-11092	BMS-509744	Inhibitor	98.05%	Unkown
HY-12680	PRN694	Inhibitor	≥99.0%	Unkown
HY-108691	PF-06465469	Inhibitor	99.48%	Unkown
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-101321A	Immepip dihydrobromide	Degrader	99.98%	Unkown
HY-128726	ITK inhibitor 2	Inhibitor	99.50%	Unkown
HY-12410	GNE-9822	Inhibitor	98.47%	Unkown
HY-169396	TAE648	Ligand	99.50%	Unkown
HY-120559	GSK-2250665A	Inhibitor	96.35%	Unkown
HY-185206	BSJ-05-037	Degrader	99.83%	Unkown
HY-174280	Modzatinib	Inhibitor	/	Unkown
HY-150023	BI-1622	Inhibitor	98.02%	Unkown
HY-146672	ITK inhibitor 6	Inhibitor	/	Unkown
HY-13232	ITK antagonist	Inhibitor	/	Unkown
HY-174903	ITK-IN-6	Inhibitor	99.02%	Unkown
HY-149917	PROTAC ITK degrader 1	Degrader	/	Unkown
HY-N6857C	(±)-Armepavine hydrochloride		/	Unkown
HY-184275	ITK-IN-7	Inhibitor	/	Unkown
HY-16984	GNE-4997	Inhibitor	/	Unkown
HY-168963	PROTAC BTK Degrader-13	Inhibitor	/	Unkown
HY-182335	PF-07245303	Inhibitor	/	Unkown
HY-168387	ITK ligand 1	Inhibitor	/	Unkown
HY-153322	ITK degrader 2	Degrader	/	Unkown
HY-141864	ITK/TRKA-IN-1	Inhibitor	/	Unkown
HY-146671	ITK inhibitor 5	Inhibitor	/	Unkown
HY-E70833	ITK Recombinant Human Active Protein Kinase		/	Unkown
HY-143901	EGFR-IN-40	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ITK	VGNC	VGNC:30338
Macaca mulatta	ITK	VGNC	VGNC:73797
Rattus norvegicus	ITK	RGD	RGD:1311618
Mus musculus	ITK	MGD	MGI:96621
Canis familiaris	ITK	VGNC	VGNC:42149
Felis catus	ITK	VGNC	VGNC:67863
Others	ITK	NCBI