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URM1 - ubiquitin related modifier 1 Gene

Also Known as C9orf74

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81605

About URM1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,371,319-128,392,016 (from NCBI)

This gene has 5 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in spleen (RPKM 8.1), lymph node (RPKM 7.6) and 25 other tissues.

Summary

Enables sulfur carrier activity. Involved in tRNA thio-modification and tRNA wobble uridine modification. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

URM1 Products (3)

mRNA	Protein	Name
NM_001135947.2	NP_001129419.1	ubiquitin-related modifier 1 isoform b
NM_001265582.1	NP_001252511.1	ubiquitin-related modifier 1 isoform c
NM_030914.4	NP_112176.1	ubiquitin-related modifier 1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19017811	GOA
enables sulfur carrier activity	IDA IDA: Inferred from direct assay	19017811	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in tRNA thio-modification	IMP IMP: Inferred from mutant phenotype	19017811	GOA
involved in tRNA wobble uridine modification	IMP IMP: Inferred from mutant phenotype	19017811	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

URM1 Protein Structure

Urm1

0
101 a.a.

Protein Preferred Names	Protein Names
ubiquitin-related modifier 1	ubiquitin-related modifier 1 homolog

URM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	URM1	Q9BTM9	USP15	Homo sapiens	Q9Y4E8	Anti Tag CoIP	21209336
Intra	URM1	Q9BTM9	CTU1	Homo sapiens	Q7Z7A3	Anti Tag CoIP	21209336
Intra	URM1	Q9BTM9	CTU1	Homo sapiens	Q7Z7A3	Anti Tag CoIP	19017811
Intra	URM1	Q9BTM9	CTU1	Homo sapiens	Q7Z7A3	Comig Non-Denat Gel	19017811
Intra	URM1	Q9BTM9	CSE1L	Homo sapiens	P55060	Anti Tag CoIP	21209336
Intra	URM1	Q9BTM9	MOCS3	Homo sapiens	O95396	Anti Tag CoIP	21209336
Intra	URM1	Q9BTM9	MOCS3	Homo sapiens	O95396	Comigration in SDS	21209336

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neuropathy, Hereditary Sensory And Autonomic, Type Iii	Familial Dysautonomia Riley-Day Syndrome Dysautonomia, Familial HSAN3 Hsan Iii Fd Hereditary Sensory And Autonomic Neuropathy Type Iii Dys Hereditary Sensory And Autonomic Neuropathy 3 Riley Day Syndrome Familial Autonomic Nervous Dysfunction Hereditary Sensory Autonomic Neuropathy Type Iii Hsan 3 Hsn 3 Hereditary Sensory Neuropathy Type 3 Hsan Type Iii Hsn-Iii Hereditary Sensory And Autonomic Neuropathy Type 3 Neuropathy, Hereditary Sensory And Autonomic, 3 Hsn Iii Dysautonomia Familial Neuropathy, Sensory And Autonomic, Hereditary, Type Iii Hsan3 - [Hereditary Sensory And Autonomic Neuropathy Type 3]
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS15508	URM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19650	Urm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26143	Urm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	URM1	VGNC	VGNC:79704
Bos taurus	URM1	VGNC	VGNC:36699
Mus musculus	URM1	MGD	MGI:1915455
Rattus norvegicus	URM1	RGD	RGD:1306599
Felis catus	URM1	VGNC	VGNC:66854
Canis familiaris	URM1	VGNC	VGNC:48167
Others	URM1	NCBI