Keap1-IN-2
Keap1-IN-2 (Compound 164) is a KEAP1 inhibitor (IC50: 2 nM). Keap1-IN-2 indirectly activates Nrf2 by inhibiting KEAP1, thereby enhancing the antioxidant capacity of cells. Keap1-IN-2 promotes the accumulation and nuclear translocation of Nrf2 by blocking KEAP1-mediated Nrf2 degradation. Keap1-IN-2 can be used to study diseases associated with oxidative stress, such as inflammatory bowel disease, Crohn's disease, and immune diseases such as ulcerative colitis.
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- CAS. Nr.: 3066895-41-5
- Formel: C21H23ClN6O3
- Molecular Weight:442.90
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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CAS. Nr. 3066895-41-5
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Molecular Weight 442.90
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Formel C21H23ClN6O3
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SMILES
CC(N1[C@H](C2=CC(Cl)=NC(C3=NC=NC(C(NC)=O)=C3)=C2)CN(C[C@H]1C)C(C=C)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Keap1-IN-2 Related Classifications
HY-174287 Related Classifications
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