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Art. -Nr.: HY-P10331

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KSL 128114

Name: KSL 128114
Brand: MedChemExpress
SKU: HY-P10331
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

KSL 128114, a peptide inhibitor of syntenin, binds the PDZ1 domain of syntenin with nanomolar affinity. KSL 128114 is resistant toward degradation in human plasma and mouse hepatic microsomes and displays a global PDZ domain selectivity for syntenin.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2757292-12-7
Formel: C₉₆H₁₆₅N₃₉O₂₁
Molecular Weight:2201.59

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Please store the product under the recommended conditions in the Certificate of Analysis.

KSL 128114 Chemical Structure

CAS. Nr.: 2757292-12-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

KSL-128114 (~20 μM) shows an inhibitory effect on primary GBM cell viability and significantly extends survival time in a patient-derived xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2757292-12-7
Molecular Weight 2201.59
Formel C₉₆H₁₆₅N₃₉O₂₁
Sequence

Ac-{d-Arg}-Arg-{d-Arg}-Gly-{d-Arg}-Lys-{d-Lys}-Arg-{d-Arg}-Ser-His-Trp-{Tle}-{Chg}-Asp-Ile
Sequence Shortening

Ac-{d-Arg}-R-{d-Arg}-G-{d-Arg}-K-{d-Lys}-R-{d-Arg}-SHW-{Tle}-{Chg}-DI
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Eur J Med Chem

Design, synthesis, and biological evaluation of novel and highly potent peptides targeting syntenin. [Abstract]

2025 May 5:289:117446. PMID: 40020425

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Linda M Haugaard-Kedström, et al. A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma. J Med Chem. 2021 Feb 11;64(3):1423-1434. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

KSL 128114

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise

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KSL 128114

Publications Citing Use of MedChemExpress (MCE) KSL 128114