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Art. -Nr.: HY-179027

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LDH-IN-5

LDH-IN-5 is a Lactate Dehydrogenase (LDH) inhibitor with neuroprotective activity. LDH-IN-5 can inhibit cell apoptosis, reduce ROS, MDA production and increases superoxide dismutase (SOD) activity. LDH-IN-5 can be used for the research of neurological disease, such as ischemic stroke.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2768522-31-0
Formel: C₃₆H₅₁BrO₆
Molecular Weight:659.69

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

LDH-IN-5 Chemical Structure

CAS. Nr.: 2768522-31-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

LDH-IN-5 (Compound s6b) (12.5-50 μM, 6h) significantly increases cell viability and reduces LDH release in mouse hippocampal neuron HT22 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LDH-IN-5 (Compound s6b) (125-500 μg/mL, 18 h) significantly reduces the incidence of cerebral thrombosis in 2dpf albino zebrafish models induced by Ponatinib (HY-12047)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

2dpf albino zebrafish models induced by Ponatinib (HY-12047)^[1]
Dosage:

125-500 μg/mL
Administration:

18 h
Result:

Showed the thrombosis incidence decreases by 97% in the 125 μg/mL dose group and 77% in the 500 μg/mL dose group.
Showed no zebrafish death or obvious toxicity at 500 μg/mL.

Chemical Information

CAS. Nr. 2768522-31-0
Molecular Weight 659.69
Formel C₃₆H₅₁BrO₆
SMILES

CC1(C)[C@@]2(C)[C@H](OC(CCC(O[C@H](C3=CC=C(Br)C=C3C(O[C@H]4[C@@](C5(C)C)(C)CC[C@H]5C4)=O)CCCC)=O)=O)C[C@@H]1CC2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang X, et al. Design, synthesis and evaluation of NBP/borneol hybrids as neuroprotective agents for the treatment of ischemic stroke. Bioorg Chem. 2025 Oct;165:109056. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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