Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
54 Results for "
synaptic blocking
" in MedChemExpress (MCE) Product Catalog:
Products (54)
54 Results for "synaptic blocking" in MCE Product Catalog:
Art. -Nr.: HY-A0022
CAS. Nr.: 24853-80-3
Synonyms: Azafen; Pipofezin hydrochloride; Pipofezine hydrochloride
Category:
Target:
Art. -Nr.: HY-W004464
CAS. Nr.: 20980-22-7
Art. -Nr.: HY-100714B
CAS. Nr.: 79055-67-7
Synonyms: L-APV; L-2-Amino-5-phosphonovaleric acid
Target:
Forschungsgebiete:
L-AP5 (L-APV; L-2-Amino-5-phosphonovaleric acid) is an NMDA antagonist and is the isomer of D-AP5 (HY-100714A).
L-AP5 shows a relatively weak amino acid and synaptic blocking activity .
Art. -Nr.: HY-107605
CAS. Nr.: 745055-86-1
Target:
Forschungsgebiete:
UBP296 is a potent and selective antagonist of GLUK5-containing kainate receptor in the spinal cord. UBP296 reversibly blocks ATPA-induced depressions of synaptic transmission, and affects AMPA receptor-mediated synaptic transmission directly in rat hippocampal slices .
Art. -Nr.: HY-P1054
CAS. Nr.: 1315378-67-6
Synonyms: YNVYGIEEVKI
Target:
Forschungsgebiete:
Art. -Nr.: HY-100785A
CAS. Nr.: 2935387-13-4
Synonyms: γDGG acetate; γ-D-Glutamylglycine acetate
Target:
Forschungsgebiete:
gamma-DGG acetate (γDGG acetate) is a competitive AMPA receptor blocker. gamma-DGG acetate is also a reversible Excitatory post-synaptic potentials (e.p.s.p.s) antagonist .
Art. -Nr.: HY-P0062A
Synonyms: SNX-111 TFA
Target:
Forschungsgebiete:
Art. -Nr.: HY-169871
CAS. Nr.: 105029-41-2
Category:
Target:
Art. -Nr.: HY-P10630
CAS. Nr.: 1781242-18-9
Target:
Forschungsgebiete:
Art. -Nr.: HY-175300
CAS. Nr.: 2421120-68-3
Target:
Forschungsgebiete:
AChE-IN-92 (Compound L4R1-3) is a highly selective acetylcholinesterase (AChE) inhibitor (IC50=4.6 nM). AChE-IN-92 blocks acetylcholine hydrolysis and elevates synaptic acetylcholine levels. AChE-IN-92 is promising for research of Alzheimer’s disease (AD) .
Forschungsgebiete:
Tetrabenazine (Ro 1-9569) mesylate is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 Ki 100 nM. Tetrabenazine mesylate binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine mesylate weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine mesylate can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .
Art. -Nr.: HY-B1789
CAS. Nr.: 80880-90-6
Target:
Forschungsgebiete:
Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM) .
Art. -Nr.: HY-108578
CAS. Nr.: 851956-02-0
Target:
Forschungsgebiete:
RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged Kv channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation .
Forschungsgebiete:
Tetrabenazine (Standard) is the analytical standard of Tetrabenazine (HY-B0590). This product is intended for research and analytical applications. Tetrabenazine (Ro 1-9569) is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 Ki 100 nM. Tetrabenazine binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .
Art. -Nr.: HY-B0590S3
CAS. Nr.: 2701977-99-1
Synonyms: TBZ-d7-d7; Ro 1-9569-d7
Art. -Nr.: HY-W278867R
CAS. Nr.: 21956-56-9
Synonyms: trans-Pinosylvin dimethyl ether (Standard)
Art. -Nr.: HY-W004464R
CAS. Nr.: 20980-22-7
Category:
Art. -Nr.: HY-103430
CAS. Nr.: 108179-91-5
Forschungsgebiete:
SKF-83566 hydrobromide is an orally active, blood-brain barrier-permeable D1/D5 dopamine receptor antagonist with a Ki value of approximately 0.4-0.56 nM.
SKF-83566 hydrobromide modulates locomotor behavior and spatial memory by blocking D1 receptors and inhibits glioblastoma progression by targeting the DRD1/c-Myc/UHRF1 pathway.
SKF-83566 hydrobromide acts as an inhibitor of the dopamine transporter (DAT) and adenylyl cyclase 2 (AC2).
SKF-83566 hydrobromide competitively binds to DAT to inhibit dopamine reuptake and non-competitively inhibits AC2 activity, thereby reducing cAMP accumulation.
SKF-83566 hydrobromide is used in research areas such as dopaminergic system mechanisms, learning and memory, targeted intervention for glioblastoma, AC2 pathophysiology, antiparasitic drug screening, and synaptic plasticity (the "gating effect") .
Art. -Nr.: HY-W795736
CAS. Nr.: 112709-60-1
Synonyms: (+)-AH5183
Target:
Forschungsgebiete:
(+)-Vesamicol ((+)-AH5183) is an acetylcholine vesicular transport system inhibitor. (+)-Vesamicol blocks acetylcholine storage and uptake by synaptic vesicles, reducing transmitter availability for neuromuscular junction release. (+)-Vesamicol acts as a neuromuscular blocking agent, producing frequency-dependent neuromuscular block in rat hemidiaphragm preparations .
Art. -Nr.: HY-118278
CAS. Nr.: 161832-71-9
Synonyms: LY303070
Target:
Forschungsgebiete:
GYKI 53784 (LY303070) is an orally active, blood-brain penetrant, selective, non-competitive AMPA receptor antagonist (IC50 = 0.32 μM). GYKI 53784 completely blocks AMPA-mediated synaptic transmission, protects against excitotoxicity, and partially inhibits Kainite (Kainic acid) (HY-N2309) responses, revealing both AMPA and kainate receptors. GYKI 53784 selectively blocks synaptic transmission (IC50 = 365.3 nM) without affecting neuronal excitability, and exhibits potent stereoselective antinociceptive effects via an opioid-independent mechanism. GYKI 53784 is a versatile tool for studying AMPA receptor function in synaptic transmission, excitotoxicity, neuroprotection, pain, and inflammation, with potential relevance to hearing loss, neonatal ischemia, neurodegenerative disorders, schizophrenia, and Alzheimer's disease .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
