24853-80-3
Chemical Structure
Azaphen
Synonym(s): Azafen; Pipofezin hydrochloride; Pipofezine hydrochloride
- CAS No.: 24853-80-3
- Formula:C16H21Cl2N5O
- Molecular Weight:370.28
IUPAC Name: 5-methyl-3-(4-methylpiperazin-1-yl)-5H-benzo[b]pyridazino[4,3-e][1,4]oxazine dihydrochloride
InChIKey: ZZVWCKAYZSAUKR-UHFFFAOYSA-N
SMILES: [H]Cl.[H]Cl.CN1C2=CC=CC=C2OC3=C1C=C(N4CCN(C)CC4)N=N3
Biological Activity: Azaphen (Azafen) is an orally active tricyclic antidepressant that inhibits the reuptake of serotonin and monoamines, regulates the 5-HT2c receptor, and exerts sedative, antidepressant and anxiolytic effects. Azaphen increases the bioavailability of serotonin in the synaptic cleft, does not block muscarinic receptors or affect monoamine oxidase activity, and binds to the human serotonin transporter via salt bridges, π-stacking, π-cation and hydrophobic interactions. Azaphen can be used in studies related to depression[1][2][3].
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Azaphen | Azaphen (Azafen) is an orally active tricyclic antidepressant that inhibits the reuptake of serotonin and monoamines, regulates the 5-HT2c receptor, and exerts sedative, antidepressant and anxiolytic effects. Azaphen increases the bioavailability of serotonin in the synaptic cleft, does not block muscarinic receptors or affect monoamine oxidase activity, and binds to the human serotonin transporter via salt bridges, π-stacking, π-cation and hydrophobic interactions. Azaphen can be used in studies related to depression. | |||||||||||||||||||||
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References
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[1]. Imran M, et al. Study of various pyridazine and phthalazine drugs with diverse therapeutically and agrochemically activities. Russ J Bioorg Chem. 2020;46(5):745-767.
- [2]. Aleeva GN, et al. Comparison of antidepressant effects of azafan, tianeptine, and paroxetine. Bulletin of experimental biology and medicine. 2009 Jul;148(1):54-6.
- [3]. Lin J, et al. Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants. Advanced therapeutics. 2024 Sep;7(9):2400117.