Exo1
Based on 8 publication(s) in Google Scholar
Exo1 is a chemical inhibitor of the exocytic pathway.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 75541-83-2
- Formula: C15H12FNO3
- Molecular Weight:273.26
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Exo1
More- Bioact Mater. 2025 Oct 28:56:455-467. [Abstract]
- Bioact Mater. 2021 Jan 14;6(7):2158-2172. [Abstract]
- Biomaterials. 2026 Mar 27.
- Acta Biomater. 2025 Jun 15:200:629-640. [Abstract]
- JCI Insight. 2023 Oct 9;8(19):e160374. [Abstract]
- Int J Mol Sci. 2022 Aug 3;23(15):8634. [Abstract]
- University of Texas. 2025.
- University of Texas. 2023 Dec.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Neutrophil | IC50 |
>40 μM
Compound: 1k
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Antiinflammatory activity in neutrophil assessed as inhibition of fMLP induced elastase release
Antiinflammatory activity in neutrophil assessed as inhibition of fMLP induced elastase release
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[PMID: 17197180] |
| Neutrophil | IC50 |
>40 μM
Compound: 1k
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Antiinflammatory activity in neutrophils assessed as inhibition of oxygen radical generation
Antiinflammatory activity in neutrophils assessed as inhibition of oxygen radical generation
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[PMID: 17197180] |
| Platelet | IC50 |
>100 μM
Compound: 1k
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Anticoagulant activity assessed as inhibition of arachidonic acid induced rabbit platelet aggregation
Anticoagulant activity assessed as inhibition of arachidonic acid induced rabbit platelet aggregation
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[PMID: 17197180] |
| Platelet | IC50 |
>100 μM
Compound: 1k
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Anticoagulant activity assessed as inhibition of thrombin induced rabbit platelet aggregation
Anticoagulant activity assessed as inhibition of thrombin induced rabbit platelet aggregation
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[PMID: 17197180] |
Exo1 is a modifier of Golgi ARF1 GTPase activity. Because Exo1 affects a subset of the membrane events that are blocked by BFA, but seems to have a different protein target (and presumably has different side effects), it provides an independent means to interfere with Golgi activity. Exo1 Disrupts Vesicular Traffic from the ER to the Golgi apparatus by disrupting Golgi structures. Exo1 inhibits exocytosis with an IC50 of ~20 μM. Exo1 prevents acquisition of endoglycosidase H resistance by newly synthesized proteins such as VSVGts-GFP, transferrin, and MHC class I[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 75541-83-2
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Appearance Solid
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Molecular Weight 273.26
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Formula C15H12FNO3
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Color White to off-white
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SMILES
O=C(OC)C1=CC=CC=C1NC(C2=CC=C(F)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (8)
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Journal Impact Factor
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Most Recent
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Bioact Mater
Dynamic matrix engineering promotes nascent protein deposition to drive cell migration and expedite Re-epithelization in chronic wound. [Abstract]2025 Oct 28:56:455-467. PMID: 41216373 -
Bioact Mater
Antibody-activated trans-endothelial delivery of mesoporous organosilica nanomedicine augments tumor extravasation and anti-cancer immunotherapy. [Abstract]2021 Jan 14;6(7):2158-2172. PMID: 33511314 -
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Acta Biomater
Enhanced delivery of camptothecin to colorectal carcinoma using a tumor-penetrating peptide targeting p32. [Abstract]2025 Jun 15:200:629-640. PMID: 40379119 -
JCI Insight
RhoA vesicle trafficking-mediated transglutaminase 2 membrane translocation promotes IgA1 mesangial deposition in IgA nephropathy. [Abstract]2023 Oct 9;8(19):e160374. PMID: 37811653 -
Int J Mol Sci
The Deficiency of SCARB2/LIMP-2 Impairs Metabolism via Disrupted mTORC1-Dependent Mitochondrial OXPHOS. [Abstract]2022 Aug 3;23(15):8634. PMID: 35955761 -
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Solvent & Solubility
DMSO : 25 mg/mL (91.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6595 mL | 18.2976 mL | 36.5952 mL | 91.4880 mL |
| 5 mM | 0.7319 mL | 3.6595 mL | 7.3190 mL | 18.2976 mL | |
| 10 mM | 0.3660 mL | 1.8298 mL | 3.6595 mL | 9.1488 mL | |
| 15 mM | 0.2440 mL | 1.2198 mL | 2.4397 mL | 6.0992 mL | |
| 20 mM | 0.1830 mL | 0.9149 mL | 1.8298 mL | 4.5744 mL | |
| 25 mM | 0.1464 mL | 0.7319 mL | 1.4638 mL | 3.6595 mL | |
| 30 mM | 0.1220 mL | 0.6099 mL | 1.2198 mL | 3.0496 mL | |
| 40 mM | 0.0915 mL | 0.4574 mL | 0.9149 mL | 2.2872 mL | |
| 50 mM | 0.0732 mL | 0.3660 mL | 0.7319 mL | 1.8298 mL | |
| 60 mM | 0.0610 mL | 0.3050 mL | 0.6099 mL | 1.5248 mL | |
| 80 mM | 0.0457 mL | 0.2287 mL | 0.4574 mL | 1.1436 mL |
Exo1 Related Classifications
HY-112670 Related Classifications
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