Azido-PEG1-C2-acid
Based on 1 Customer Validation
Azido-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1393330-34-1
- Formula: C5H9N3O3
- Molecular Weight:159.14
-
Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
|
PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1393330-34-1
-
Appearance Liquid
-
Molecular Weight 159.14
-
Formula C5H9N3O3
-
Color Colorless to light yellow
-
SMILES
O=C(O)CCOCCN=[N+]=[N-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (628.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (267 KB)
-
SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Portuguese - PT (557 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.2838 mL | 31.4189 mL | 62.8378 mL | 157.0944 mL |
| 5 mM | 1.2568 mL | 6.2838 mL | 12.5676 mL | 31.4189 mL | |
| 10 mM | 0.6284 mL | 3.1419 mL | 6.2838 mL | 15.7094 mL | |
| 15 mM | 0.4189 mL | 2.0946 mL | 4.1892 mL | 10.4730 mL | |
| 20 mM | 0.3142 mL | 1.5709 mL | 3.1419 mL | 7.8547 mL | |
| 25 mM | 0.2514 mL | 1.2568 mL | 2.5135 mL | 6.2838 mL | |
| 30 mM | 0.2095 mL | 1.0473 mL | 2.0946 mL | 5.2365 mL | |
| 40 mM | 0.1571 mL | 0.7855 mL | 1.5709 mL | 3.9274 mL | |
| 50 mM | 0.1257 mL | 0.6284 mL | 1.2568 mL | 3.1419 mL | |
| 60 mM | 0.1047 mL | 0.5236 mL | 1.0473 mL | 2.6182 mL | |
| 80 mM | 0.0785 mL | 0.3927 mL | 0.7855 mL | 1.9637 mL | |
| 100 mM | 0.0628 mL | 0.3142 mL | 0.6284 mL | 1.5709 mL |
Powered by Bioz