2. PROTAC
  3. PROTAC Linkers
  4. Azido-PEG1-C2-acid

Azido-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Azido-PEG1-C2-acid Chemical Structure

Azido-PEG1-C2-acid Chemical Structure

CAS No. : 1393330-34-1

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Based on 1 publication(s) in Google Scholar

Azido-PEG1-C2-acid Related Antibodies

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Description

Azido-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azido-PEG1-C2-acid Related Antibodies
Molecular Weight

159.14

Formula

C5H9N3O3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (628.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.2838 mL 31.4189 mL 62.8377 mL
5 mM 1.2568 mL 6.2838 mL 12.5676 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.2838 mL 31.4189 mL 62.8378 mL 157.0944 mL
5 mM 1.2568 mL 6.2838 mL 12.5676 mL 31.4189 mL
10 mM 0.6284 mL 3.1419 mL 6.2838 mL 15.7094 mL
15 mM 0.4189 mL 2.0946 mL 4.1892 mL 10.4730 mL
20 mM 0.3142 mL 1.5709 mL 3.1419 mL 7.8547 mL
25 mM 0.2514 mL 1.2568 mL 2.5135 mL 6.2838 mL
30 mM 0.2095 mL 1.0473 mL 2.0946 mL 5.2365 mL
40 mM 0.1571 mL 0.7855 mL 1.5709 mL 3.9274 mL
50 mM 0.1257 mL 0.6284 mL 1.2568 mL 3.1419 mL
60 mM 0.1047 mL 0.5236 mL 1.0473 mL 2.6182 mL
80 mM 0.0785 mL 0.3927 mL 0.7855 mL 1.9637 mL
100 mM 0.0628 mL 0.3142 mL 0.6284 mL 1.5709 mL
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Azido-PEG1-C2-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azido-PEG1-C2-acid1393330-34-1PROTAC LinkersInhibitorinhibitorinhibit

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