2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Batracylin

Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks.

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Batracylin

Batracylin 화학구조

CAS No. : 67199-66-0

사이즈 가격 재고 수량
1 mg 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
5 mg 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
10 mg 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
25 mg 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 mg 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 mg 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
500 mg 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
1 g   견적 받기  
5 g   견적 받기  
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Batracylin Related Antibodies

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Topoisomerase Topo I Topo II DNA gyrase

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제품 설명

Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
46.3 μM
Compound: BAT; Batracylin
Cytotoxicity against human A549 cells after 120 hrs by MTT assay
Cytotoxicity against human A549 cells after 120 hrs by MTT assay
[PMID: 26520842]
CCRF-CEM IC50
14 μM
Compound: 1
Tested for the inhibitory activity against CCRF CEM T- cell leukemia cells
Tested for the inhibitory activity against CCRF CEM T- cell leukemia cells
[PMID: 7932571]
HCT-116 IC50
88.7 μM
Compound: BAT; Batracylin
Cytotoxicity against human HCT116 cells after 120 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 120 hrs by MTT assay
[PMID: 26520842]
HL-60 IC50
66.6 μM
Compound: BAT; Batracylin
Cytotoxicity against human HL60 cells after 120 hrs by MTT assay
Cytotoxicity against human HL60 cells after 120 hrs by MTT assay
[PMID: 26520842]
HT-29 IC50
64.3 μM
Compound: BAT; Batracylin
Cytotoxicity against human HT-29 cells after 120 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 120 hrs by MTT assay
[PMID: 26520842]
L1210 IC50
>100 μM
Compound: BAT; Batracylin
Cytotoxicity against mouse L1210 cells after 120 hrs by MTT assay
Cytotoxicity against mouse L1210 cells after 120 hrs by MTT assay
[PMID: 26520842]
LNCaP IC50
90.2 μM
Compound: BAT; Batracylin
Cytotoxicity against human LNCAP cells after 120 hrs by MTT assay
Cytotoxicity against human LNCAP cells after 120 hrs by MTT assay
[PMID: 26520842]
MCF7 IC50
>100 μM
Compound: BAT; Batracylin
Cytotoxicity against human MCF7 cells after 120 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 120 hrs by MTT assay
[PMID: 26520842]
NIH3T3 IC50
69.9 μM
Compound: BAT; Batracylin
Cytotoxicity against mouse NIH/3T3 cells after 120 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells after 120 hrs by MTT assay
[PMID: 26520842]
P388 IC50
>100 μM
Compound: BAT; Batracylin
Cytotoxicity against mouse P388 cells after 120 hrs by MTT assay
Cytotoxicity against mouse P388 cells after 120 hrs by MTT assay
[PMID: 26520842]
In Vitro

Batracylin (0-300 µM; 6 h) shows cytotoxicity with an IC50 value of 10.02 µM for HT29 cells[1].
Batracylin (100, 300 µM; 3 h) induces protein-linked DNA breaks consistent with topoisomerase targeting[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Batracylin Related Antibodies
Clinical Trial
분자량

249.27

화학식

C15H11N3O
CAS No.
SMILES

O=C1C2=C(C=CC=C2)C3=NC4=C(CN31)C=C(C=C4)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Batracylin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Batracylin67199-66-0NSC 320846 BAY-H 2049NSC320846NSC-320846TopoisomeraseHT29 cellsDNA breaksγ-H2AXcytotoxicityInhibitorinhibitorinhibit

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상품명:
Batracylin
Cat. No.:
HY-119892
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