Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid
Based on 1 Customer Validation
Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity : 99.92%
- CAS No.: 56842-95-6
- Formula: C7H8O4
- Molecular Weight:156.14
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
![Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid Chemical Structure](https://file.medchemexpress.com/product_pic/hy-w000132.gif "Click to View Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid Chemical Structure")
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
![3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w001056.gif)
All PROTAC Linkers Isoforms
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E511 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 56842-95-6
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Appearance Solid
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Molecular Weight 156.14
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Formula C7H8O4
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Color White to off-white
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SMILES
O=C(O)C12CC(C(=O)O)(C1)C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (640.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (243 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4045 mL | 32.0225 mL | 64.0451 mL | 160.1127 mL |
| 5 mM | 1.2809 mL | 6.4045 mL | 12.8090 mL | 32.0225 mL | |
| 10 mM | 0.6405 mL | 3.2023 mL | 6.4045 mL | 16.0113 mL | |
| 15 mM | 0.4270 mL | 2.1348 mL | 4.2697 mL | 10.6742 mL | |
| 20 mM | 0.3202 mL | 1.6011 mL | 3.2023 mL | 8.0056 mL | |
| 25 mM | 0.2562 mL | 1.2809 mL | 2.5618 mL | 6.4045 mL | |
| 30 mM | 0.2135 mL | 1.0674 mL | 2.1348 mL | 5.3371 mL | |
| 40 mM | 0.1601 mL | 0.8006 mL | 1.6011 mL | 4.0028 mL | |
| 50 mM | 0.1281 mL | 0.6405 mL | 1.2809 mL | 3.2023 mL | |
| 60 mM | 0.1067 mL | 0.5337 mL | 1.0674 mL | 2.6685 mL | |
| 80 mM | 0.0801 mL | 0.4003 mL | 0.8006 mL | 2.0014 mL | |
| 100 mM | 0.0640 mL | 0.3202 mL | 0.6405 mL | 1.6011 mL |
Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid Related Classifications
HY-W000132 Related Classifications
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