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Cat. No.: HY-187100

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Bis(4-methylphenyl) diselenide

Bis(4-methylphenyl) diselenide is a symmetric aromatic organodiselenide with in vitro cytotoxicity against cancer cells. Bis(4-methylphenyl) diselenide can be used for the research of promyelocytic leukemia, epithelial carcinoma, renal cell adenocarcinoma, colorectal adenocarcinoma, and prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 21856-94-0
Formula: C₁₄H₁₄Se₂
Molecular Weight:340.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bis(4-methylphenyl) diselenide Chemical Structure

CAS No.: 21856-94-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC50	33 μM	Antiproliferative (cytotoxic) activity against human promyelocytic leukemia HL-60 cells assessed by MTT assay after 48 h incubation. Antiproliferative (cytotoxic) activity against human promyelocytic leukemia HL-60 cells assessed by MTT assay after 48 h incubation.	24961641
OVCAR-5	IC50	31 μM	Antiproliferative (cytotoxic) activity against human epithelial carcinoma OVCAR-5 cells assessed by MTT assay after 48 h incubation. Antiproliferative (cytotoxic) activity against human epithelial carcinoma OVCAR-5 cells assessed by MTT assay after 48 h incubation.	24961641
786-0	IC50	29 μM	Antiproliferative (cytotoxic) activity against human renal cell adenocarcinoma 786-O cells assessed by MTT assay after 48 h incubation. Antiproliferative (cytotoxic) activity against human renal cell adenocarcinoma 786-O cells assessed by MTT assay after 48 h incubation.	24961641
HT-29	IC50	37 μM	Antiproliferative (cytotoxic) activity against human colorectal adenocarcinoma HT-29 cells assessed by MTT assay after 48 h incubation. Antiproliferative (cytotoxic) activity against human colorectal adenocarcinoma HT-29 cells assessed by MTT assay after 48 h incubation.	24961641
PC-3	IC50	29 μM	Antiproliferative (cytotoxic) activity against human prostate cancer PC-3 cells assessed by MTT assay after 48 h incubation. Antiproliferative (cytotoxic) activity against human prostate cancer PC-3 cells assessed by MTT assay after 48 h incubation.	24961641

In Vitro

Bis(4-methylphenyl) diselenide (Compound 3) (48 h) inhibits proliferation of HL-60, OVCAR-5, 786-O, HT-29, and PC-3 human cancer cell lines with IC₅₀ values ranging from 29 to 37 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 21856-94-0
Molecular Weight 340.18
Formula C₁₄H₁₄Se₂
SMILES

CC(C=C1)=CC=C1[Se][Se]C2=CC=C(C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rizvi MA, et al. An investigation of in vitro cytotoxicity and apoptotic potential of aromatic diselenides. Bioorganic & medicinal chemistry letters. 2014 Aug 01;24(15):3440-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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