Boc-6-aminohexanoic acid

Name: Boc-6-aminohexanoic acid
Brand: MedChemExpress
SKU: HY-W007529
Rating: 4.5 (1 reviews)

Cat. No.: HY-W007529: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Boc-6-aminohexanoic acid Chemical Structure

CAS No. : 6404-29-1

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
1 g	USD 30	In-stock	Estimated Time of Arrival: December 31
5 g	USD 60	In-stock	Estimated Time of Arrival: December 31
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50 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

231.29

Formula

C₁₁H₂₁NO₄

CAS No.

6404-29-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCCCNC(OC(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (216.18 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3236 mL	21.6179 mL	43.2358 mL
5 mM	0.8647 mL	4.3236 mL	8.6472 mL
10 mM	0.4324 mL	2.1618 mL	4.3236 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (267 KB) SDS (392 KB)

COA (242 KB) HNMR (125 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.3236 mL	21.6179 mL	43.2358 mL	108.0894 mL
	5 mM	0.8647 mL	4.3236 mL	8.6472 mL	21.6179 mL
	10 mM	0.4324 mL	2.1618 mL	4.3236 mL	10.8089 mL
	15 mM	0.2882 mL	1.4412 mL	2.8824 mL	7.2060 mL
	20 mM	0.2162 mL	1.0809 mL	2.1618 mL	5.4045 mL
	25 mM	0.1729 mL	0.8647 mL	1.7294 mL	4.3236 mL
	30 mM	0.1441 mL	0.7206 mL	1.4412 mL	3.6030 mL
	40 mM	0.1081 mL	0.5404 mL	1.0809 mL	2.7022 mL
	50 mM	0.0865 mL	0.4324 mL	0.8647 mL	2.1618 mL
	60 mM	0.0721 mL	0.3603 mL	0.7206 mL	1.8015 mL
	80 mM	0.0540 mL	0.2702 mL	0.5404 mL	1.3511 mL
	100 mM	0.0432 mL	0.2162 mL	0.4324 mL	1.0809 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.