Brimonidine-d4 D-tartrate
Based on 1 Customer Validation
Brimonidine-d4 (D-tartrate) is the deuterium labeled Brimonidine D-tartrate.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 1316758-27-6
- Formula: C15H12D4BrN5O6
- Molecular Weight:446.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1316758-27-6
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Unlabeled Cas 1350706-20-5
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Appearance Solid
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Molecular Weight 446.25
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Formula C15H12D4BrN5O6
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Color Light yellow to yellow
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SMILES
OC([C@@H](O)[C@H](O)C(O)=O)=O.BrC1=C(NC2=NC([2H])([2H])C([2H])([2H])N2)C=CC3=C1N=CC=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (112.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 25 mg/mL (56.02 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.2409 mL | 11.2045 mL | 22.4090 mL | 56.0224 mL |
| 5 mM | 0.4482 mL | 2.2409 mL | 4.4818 mL | 11.2045 mL | |
| 10 mM | 0.2241 mL | 1.1204 mL | 2.2409 mL | 5.6022 mL | |
| 15 mM | 0.1494 mL | 0.7470 mL | 1.4939 mL | 3.7348 mL | |
| 20 mM | 0.1120 mL | 0.5602 mL | 1.1204 mL | 2.8011 mL | |
| 25 mM | 0.0896 mL | 0.4482 mL | 0.8964 mL | 2.2409 mL | |
| 30 mM | 0.0747 mL | 0.3735 mL | 0.7470 mL | 1.8674 mL | |
| 40 mM | 0.0560 mL | 0.2801 mL | 0.5602 mL | 1.4006 mL | |
| 50 mM | 0.0448 mL | 0.2241 mL | 0.4482 mL | 1.1204 mL | |
| DMSO | 60 mM | 0.0373 mL | 0.1867 mL | 0.3735 mL | 0.9337 mL |
| 80 mM | 0.0280 mL | 0.1401 mL | 0.2801 mL | 0.7003 mL | |
| 100 mM | 0.0224 mL | 0.1120 mL | 0.2241 mL | 0.5602 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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