Nf2 - NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Gene

Also Known as merlin

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25744

Summary

Enables beta-catenin binding activity; Integrin binding activity; and protein domain specific binding activity. Involved in negative regulation of cell growth. Located in several cellular components, including membrane raft; perinuclear region of cytoplasm; and synapse. Part of protein-containing complex. Biomarker of epilepsy. Human ortholog(s) of this gene implicated in familial meningioma; neurilemmomatosis; and neurofibromatosis 2. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Apr 2022]

Nf2 Products (1)

mRNA Protein Name
NM_013193.1 NP_037325.1 merlin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
15659388 RGD
enables integrin binding IPI
IPI: Inferred from physical interaction
9858254 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15659388 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11316791 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
11316791 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9858254 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11316791 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

merlin

  • moesin-ezrin-radixin-like protein

  • neurofibromatosis 2

  • neurofibromin-2

  • schwannomin

Nf2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nf2 Q63648 Amot Rattus norvegicus A0A0G2JX94
Anti Bait CoIP
21481793
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-400902 VT3989 99.61% Unkown
HY-134955 VT103 Inhibitor 99.64% Unkown
HY-158342 PROTAC TEAD degrader-1 Degrader 99.82% Unkown
HY-163644 VT-105 Inhibitor 99.93% Unkown
HY-155309 LM-41 Inhibitor 99.87% Unkown
HY-155310 AF-2112 Inhibitor 99.82% Unkown
HY-113821 1-Naphthyl phosphate potassium salt Inhibitor 99.86% Unkown
HY-162012 HC-258 / Unkown
HY-181532 IAP ligand 8 Ligand / Unkown
HY-182672 VT101 Inhibitor / Unkown
HY-183728 LC-TEAD01 Inhibitor / Unkown
HY-RS09234 NF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181607 TEAD ligand-Linker Conjugate 3 Degrader / Unkown
HY-RS16884 Nf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23326 Nf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nf2 NCBI NCBI:4771