PHGDH-IN-2
PHGDH-IN-2 is a potent and NAD+ competitive PHGDH inhibitor with an IC50 of 5.2 µM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells.
For research use only. We do not sell to patients.
- Formula: C22H20N4O3S
- Molecular Weight:420.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PHGDH[1]
PHGDH-IN-2 (compound C25) (10, 30 µM) inhibits the serine synthetic pathway in MDA-MB-468 cells[1].
PHGDH-IN-2 (72 h) inhibits the growth of PHGDH-dependent cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-468, NCI-H1975, HCC827, PC-9, ZR-75–1, MDA-MB-231 cells
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Concentration:
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Incubation Time:72 h
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Result:Inhibited the growth of PHGDH-dependent cancer cells.
Chemical Information
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Molecular Weight 420.48
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Formula C22H20N4O3S
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SMILES
CN1C(C(NC2=CC=CC(NS(=O)(C3=CC=C(C=C3)N)=O)=C2)=O)=CC4=C1C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PHGDH-IN-2 Related Classifications
HY-145860 Related Classifications
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