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Cat. No.: HY-N9737

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(−)-Acutumine

(−)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model.

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CAS No.: 17088-50-5
Formule: C₁₉H₂₄ClNO₆
Masse moléculaire:397.85

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

(−)-Acutumine Chemical Structure

CAS No.: 17088-50-5

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

(−)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2 2.2.15	CC₅₀	>2.989 mM Compound: 3	Cytotoxicity against human Hep G2.2.15 cells Cytotoxicity against human Hep G2.2.15 cells	[PMID: 17723297]
HepG2 2.2.15	IC₅₀	>2.98 mM Compound: 3	Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of e antigen HBsAg secretion Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of e antigen HBsAg secretion	[PMID: 17723297]
HepG2 2.2.15	IC₅₀	>2.989 mM Compound: 3	Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of surface antigen HBsAg secretion Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of surface antigen HBsAg secretion	[PMID: 17723297]

Chemical Information

CAS No. 17088-50-5
Masse moléculaire 397.85
Formule C₁₉H₂₄ClNO₆
SMILES

COC([C@@]12[C@](C3)(CCN2C)[C@@]4([C@H](C1)Cl)[C@@H](C(OC)=CC4=O)O)=C(OC)C3=O
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
- Plants
- Menispermaceae
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kim CY, et al. The chloroalkaloid (-)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants. Nat Commun. 2020 Apr 20;11(1):1867. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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