Anticancer agent 47
Anticancer agent 47 (compound 4j) is a potent anticancer agent. Anticancer agent 47 shows antiproliferative activities. Anticancer agent 47 induces apoptosis and cell cycle arrest at G0/G1 phase. Anticancer agent 47 shows shows antitumor activities in vivo.
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- CAS No.: 2461795-23-1
- Formule: C19H14N2O4S
- Masse moléculaire:366.39
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.72 μM
Compound: 4j
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Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
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[PMID: 32682198] |
| A549 | IC50 |
4.55 μM
Compound: 4j
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Antiproliferative activity against human A549 cells measured after 48 hrs in presence of NQO1 inhibitor dicoumarol by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs in presence of NQO1 inhibitor dicoumarol by MTT assay
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[PMID: 32682198] |
| HepG2 | IC50 |
1.6 μM
Compound: 4j
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Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
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[PMID: 32682198] |
| L02 | IC50 |
20.98 μM
Compound: 4j
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Cytotoxicity against human L02 cells measured after 48 hrs by MTT assay
Cytotoxicity against human L02 cells measured after 48 hrs by MTT assay
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[PMID: 32682198] |
| NCI-H596 | IC50 |
7.07 μM
Compound: 4j
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Antiproliferative activity against human NCI-H596 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H596 cells measured after 48 hrs by MTT assay
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[PMID: 32682198] |
Anticancer agent 47 (compound 4j) shows antiproliferative activities with IC50s of 1.6, 0.72, 7.07 µM for HepG2, A549, H596 cells, respectively[1].
Anticancer agent 47 (0.8, 1.6, 3.2 µM; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase[1].
Anticancer agent 47 (5 µM; 5h) significantly increases ROS production[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2, H596 cells
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Concentration:0.8, 1.6, 3.2 µM
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Incubation Time:24 h
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Result:Induced apoptosis with the apoptotic cell rates were 14.23, 20.47 and 27.66% at 0.8, 1.6, 3.2 µM in HepG2 cell, respectively.
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Cell Line:HepG2 cells
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Concentration:0.8, 1.6, 3.2 µM
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Incubation Time:24 h
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Result:Showed 48.54%, 49.60% and 53.00% cells were at G0/G1 phase at 0.6, 1.2 and 2.4 µM, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice (HepG2 xenografts)[1]
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Dosage:20 mg/kg
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Administration:I.v.; once every 2 days for 19 days
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Result:Effectively inhibited tumor growth with the 58.7% tumor inhibition rate.
Chemical Information
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CAS No. 2461795-23-1
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Masse moléculaire 366.39
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Formule C19H14N2O4S
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SMILES
O=C1C2=C(NC(NC2C3=CC=CC(O)=C3)=S)C4=CC=C(OC)C=C4C1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 47 Related Classifications
HY-146040 Related Classifications
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