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Cat. No.: HY-152538

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Antitumor agent-85

Antitumor agent-85 is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-85 has highly effective anti-tumor properties.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₄H₃₃N₇
Masse moléculaire:419.57

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Antitumor agent-85 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Antitumor agent-85 is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-85 has highly effective anti-tumor properties^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	IC₅₀	2816 nM Compound: 22a	Cytotoxicity against wildtype C57BL/6J mouse cancer activated fibroblast cells assessed as inhibition of cell growth incubated for 5 days by resazurin dye based fluorescence microscopic analysis Cytotoxicity against wildtype C57BL/6J mouse cancer activated fibroblast cells assessed as inhibition of cell growth incubated for 5 days by resazurin dye based fluorescence microscopic analysis	[PMID: 36645982]

In Vitro

Antitumor agent-85 (compound 22a) stabilizes the c-MYC Pu24T, c-MYC Pu22, CKit1, CKit2, KRAS and G4 DNA structures^[1].
Antitumor agent-85 (1-10000 nM) inhibits tumor organoids and cancer activated fibroblast (CAF) cells with IC₅₀ values of 193 and 2816 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 419.57
Formule C₂₄H₃₃N₇
SMILES

CCN(CCCNC1=NC(NC2=NC3=C4CCCC4=CC=C3C(C)=N2)=NC(C)=C1)CC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Bhuma N, et al. The effect of side chain variations on quinazoline-pyrimidine G-quadruplex DNA ligands. Eur J Med Chem. 2023 Feb 15;248:115103. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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