Avotaciclib sulfate
Based on 3 publication(s) in Google Scholar
Avotaciclib (BEY1107) sulfate is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib sulfate can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib sulfate can be used in the research of cancer such as pancreatic cancer and lung cancer.
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- CAS No.: 1983984-04-8
- Formule: C13H13N7O5S
- Masse moléculaire:379.35
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Publications Citing Use of MedChemExpress (MCE) Avotaciclib sulfate
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Activité biologique
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CDK1 |
Avotaciclib (0-64 μM; 48 h) sulfate can inhibit cell proliferation and promote apoptosis in radiotherapy-resistant non-small cell lung cancer cell lines, and the effect is better when combined with PV-1019 (HY-125203)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Non-small cell lung cancer cells (H1437R, H1568R, H1703R and H1869R)
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Concentration:0, 0.1, 1, 2, 4, 8, 16, 32 and 64 μM
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Incubation Time:48 h
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Result:Inhibited the cell viability, with EC50 values of 0.918, 0.580, 0.735 and 0.662 μM for H1437R, H1568R, H1703R and H1869R, respectively.
Chemical Information
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CAS No. 1983984-04-8
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Masse moléculaire 379.35
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Formule C13H13N7O5S
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SMILES
OC1=CC=C(C2=NC(N)=NC=C2)N=C1C3=NC(N)=NC=C3.O=S(O)(O)=O
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Synonyms
BEY1107 sulfate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Clin Sci
Glutamine alleviates immunosuppression in polymicrobial sepsis by augmenting bacterial phagocytosis through sustaining the GFAT-DRP1 dependent mitochondrial calcium dynamics. [Abstract]2025 Oct 22;139(20):1163-1185. PMID: 41082631 -
Cancer Cell Int
Proapoptotic role of CDK1 in overcoming paclitaxel resistance in ovarian cancer cells in response to combined treatment with paclitaxel and duloxetine. [Abstract]2024 Dec 19;24(1):409. PMID: 39702300 -
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Avotaciclib sulfate Related Classifications
HY-137432D Related Classifications
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