1. Cell Cycle/DNA Damage
  2. CDK
  3. Avotaciclib trihydrochloride

Avotaciclib trihydrochloride  (Synonyms: BEY1107 trihydrochloride)

Cat. No.: HY-137432A Purity: 99.75%
COA Handling Instructions

Avotaciclib (BEY1107) trihydrochloride is a potent and orally active inhibitor of cyclin dependent kinase 1 (CDK1). Avotaciclib trihydrochloride can be used for the research of locally advanced or metastatic pancreatic cancer.

For research use only. We do not sell to patients.

Avotaciclib trihydrochloride Chemical Structure

Avotaciclib trihydrochloride Chemical Structure

CAS No. : 1983984-01-5

Size Price Stock Quantity
1 mg USD 155 In-stock
5 mg USD 340 In-stock
10 mg USD 540 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Avotaciclib trihydrochloride:

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Description

Avotaciclib (BEY1107) trihydrochloride is a potent and orally active inhibitor of cyclin dependent kinase 1 (CDK1). Avotaciclib trihydrochloride can be used for the research of locally advanced or metastatic pancreatic cancer[1].

IC50 & Target[1]

CDK1

 

Clinical Trial
Molecular Weight

390.66

Formula

C13H14Cl3N7O

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=CC=C(C2=NC(N)=NC=C2)N=C1C3=NC(N)=NC=C3.[H]Cl.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (12.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5598 mL 12.7989 mL 25.5977 mL
5 mM 0.5120 mL 2.5598 mL 5.1195 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.75%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5598 mL 12.7989 mL 25.5977 mL 63.9943 mL
5 mM 0.5120 mL 2.5598 mL 5.1195 mL 12.7989 mL
10 mM 0.2560 mL 1.2799 mL 2.5598 mL 6.3994 mL
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Avotaciclib trihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Avotaciclib trihydrochloride
Cat. No.:
HY-137432A
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