2. Cell Cycle/DNA Damage
  3. CDK
  4. Avotaciclib hydrochloride

Avotaciclib hydrochloride  (Synonyms: BEY1107 hydrochloride)

Cat. No.: HY-137432B Purity: 99.75%
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Avotaciclib hydrochloride is the hydrochloride form of Avotaciclib (HY-137432), a CDK1 inhibitor. Avotaciclib hydrochloride can be used for a few specific cancers, such as pancreatic cancer, in which CDK1 is abnormal and strongly expressed.

For research use only. We do not sell to patients.

Avotaciclib hydrochloride Chemical Structure

Avotaciclib hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 340 In-stock
10 mg USD 540 In-stock
25 mg USD 1050 In-stock
50 mg USD 1680 In-stock
100 mg USD 2650 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Avotaciclib hydrochloride:

Avotaciclib hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Avotaciclib hydrochloride

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Description

Avotaciclib hydrochloride is the hydrochloride form of Avotaciclib (HY-137432), a CDK1 inhibitor. Avotaciclib hydrochloride can be used for a few specific cancers, such as pancreatic cancer, in which CDK1 is abnormal and strongly expressed[1].

IC50 & Target

CDK1[1]
Clinical Trial
Molecular Weight

317.73

Formula

C13H12ClN7O
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=C(N=C(C=C1)C2=NC(N)=NC=C2)C3=CC=NC(N)=N3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (44.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1473 mL 15.7366 mL 31.4733 mL
5 mM 0.6295 mL 3.1473 mL 6.2947 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1473 mL 15.7366 mL 31.4733 mL 78.6832 mL
5 mM 0.6295 mL 3.1473 mL 6.2947 mL 15.7366 mL
10 mM 0.3147 mL 1.5737 mL 3.1473 mL 7.8683 mL
15 mM 0.2098 mL 1.0491 mL 2.0982 mL 5.2455 mL
20 mM 0.1574 mL 0.7868 mL 1.5737 mL 3.9342 mL
25 mM 0.1259 mL 0.6295 mL 1.2589 mL 3.1473 mL
30 mM 0.1049 mL 0.5246 mL 1.0491 mL 2.6228 mL
40 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.9671 mL
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Avotaciclib hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AvotaciclibBEY1107BEY 1107BEY-1107CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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