Avotaciclib hydrochloride
Based on 3 publication(s) in Google Scholar
Avotaciclib (BEY1107) hydrochloride is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib hydrochloride can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib hydrochloride can be used in the research of cancer such as pancreatic cancer and lung cancer.
For research use only. We do not sell to patients.
- Purity: 99.75%
- Formula: C13H12ClN7O
- Molecular Weight:317.73
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Orally Active Compound Library
HY-L061
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Lung Cancer Compound Library
HY-L075
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HY-L077
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HY-L079
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HY-L135
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HY-L162
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Posttranslational Modification Library
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High-Efficiency Gene Editing Compound Library
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HY-L003
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Cell Cycle/DNA Damage Compound Library
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Kinase Inhibitor Library
HY-L009
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HY-L025
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Anti-Aging Compound Library
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Publications Citing Use of MedChemExpress (MCE) Avotaciclib hydrochloride
More
Biological Activity
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CDK1 |
Avotaciclib (0-64 μM; 48 h) hydrochloride can inhibit cell proliferation and promote apoptosis in radiotherapy-resistant non-small cell lung cancer cell lines, and the effect is better when combined with PV-1019 (HY-125203)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Non-small cell lung cancer cells (H1437R, H1568R, H1703R and H1869R)
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Concentration:0, 0.1, 1, 2, 4, 8, 16, 32 and 64 μM
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Incubation Time:48 h
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Result:Inhibited the cell viability, with EC50 values of 0.918, 0.580, 0.735 and 0.662 μM for H1437R, H1568R, H1703R and H1869R, respectively.
Chemical Information
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Appearance Solid
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Molecular Weight 317.73
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Formula C13H12ClN7O
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Color Light yellow to yellow
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SMILES
OC1=C(N=C(C=C1)C2=NC(N)=NC=C2)C3=CC=NC(N)=N3.Cl
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Synonyms
BEY1107 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (3)
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Journal Impact Factor
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Most Recent
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Clin Sci
Glutamine alleviates immunosuppression in polymicrobial sepsis by augmenting bacterial phagocytosis through sustaining the GFAT-DRP1 dependent mitochondrial calcium dynamics. [Abstract]2025 Oct 22;139(20):1163-1185. PMID: 41082631 -
Cancer Cell Int
Proapoptotic role of CDK1 in overcoming paclitaxel resistance in ovarian cancer cells in response to combined treatment with paclitaxel and duloxetine. [Abstract]2024 Dec 19;24(1):409. PMID: 39702300 -
Solvent & Solubility
DMSO : 14.29 mg/mL (44.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1473 mL | 15.7366 mL | 31.4733 mL | 78.6832 mL |
| 5 mM | 0.6295 mL | 3.1473 mL | 6.2947 mL | 15.7366 mL | |
| 10 mM | 0.3147 mL | 1.5737 mL | 3.1473 mL | 7.8683 mL | |
| 15 mM | 0.2098 mL | 1.0491 mL | 2.0982 mL | 5.2455 mL | |
| 20 mM | 0.1574 mL | 0.7868 mL | 1.5737 mL | 3.9342 mL | |
| 25 mM | 0.1259 mL | 0.6295 mL | 1.2589 mL | 3.1473 mL | |
| 30 mM | 0.1049 mL | 0.5246 mL | 1.0491 mL | 2.6228 mL | |
| 40 mM | 0.0787 mL | 0.3934 mL | 0.7868 mL | 1.9671 mL |
Avotaciclib hydrochloride Related Classifications
HY-137432B Related Classifications
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