E/Z-FETPY
E/Z-FETPY is an organo-diiron(I) complex with strong cytotoxicity in cancer cell lines. E/Z-FETPY induces ferroptosis in low-differentiated cell lines, such as A2780 cells.
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- CAS No.: 3056250-97-3
- Formule: C22H24F3Fe2N2O5S2
- Masse moléculaire:629.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
E/Z-FETPY (72 h) shows cytotoxic potential that inhibits the growth of HCT 116, MCF7, and A2780 cells with IC50 values 4 μM, 2.1 μM, and 2.5 μM, respectively[1].
E/Z-FETPY (2.5 μM; 24-48 h) shows a time-dependent increase in iron uptake was detected upon incubation of A2780 cells. E/Z-FETPY suppresses hydrogen peroxide (H2O2) and peroxynitrite (O═NOO-) along with amplified production of superoxide anion (O2-) and nitric oxide (NO)[1].
FETPY (5 μM) induces significant morphological changes in murine B16-F1 and B16-F10 melanoma cells, leading to senescence and/or trans-differentiation into Schwann-like cells, thus significantly reducing their tumorigenic potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-12 weeks old C57BL/6 male or female mice injected with B16-F1 or B16-F10 cells[1]
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Dosage:4 mg/kg
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Administration:i.p.; once a day; for 3 weeks
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Result:Suppressed tumor growth in low- and high-grade syngeneic melanoma models.
Chemical Information
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CAS No. 3056250-97-3
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Masse moléculaire 629.25
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Formule C22H24F3Fe2N2O5S2
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SMILES
FC(F)(S(=O)([O-])=O)F.C[s]c1[Fe]2([N]3=CC=C(N(C)C)C=C3)([])[Fe-]1([])([CH+]#O)C2=O.[+].C4CCCC4.C5CCCC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E/Z-FETPY Related Classifications
HY-158336 Related Classifications
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