Ethyl 2-fluorocinnamate
Ethyl 2-fluorocinnamate is a substituted ethyl cinnamate derivative with antifungal activity and weak sensitizing activity. Ethyl 2-fluorocinnamate inhibits mycelial growth of phytopathogenic fungi. Ethyl 2-fluorocinnamate can be used in studies related to plant fungal diseases.
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- CAS No.: 348-13-0
- Formule: C11H11FO2
- Masse moléculaire:194.20
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Ethyl 2-fluorocinnamate (compound A11) exhibits in vitro antifungal activity against Fusarium solani, Pyricularia grisea, Valsa mali, and Botryosphaeria dothidea with an average inhibition rate of 39.3% at 0.5 mM after 72 h of incubation[1].
Ethyl 2-fluorocinnamate (compound 3b) is a weaker skin sensitizer than ethyl cinnamate, with an EC1.5 of 44.0 μM, an EC2 of 109.3 μM, an Imax of 2.8, and an IC50 of 304.2 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 348-13-0
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Masse moléculaire 194.20
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Formule C11H11FO2
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SMILES
O=C(/C=C/C1=C(F)C=CC=C1)OCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Filamentous Fungal Mold Culture and Sporulation
Filamentous fungal mold culture and sporulation assays grow hyphae under defined nutritional and environmental conditions until asexual spores, commonly conidia, are produced; the main readouts are colony growth, sporulation onset, conidial yield, conidial morphology, viability, and, when relevant, downstream infectivity or stress phenotype.
Pureté et documentation
Références
[1]. Zhou K, et al. Bioactivity and structure-activity relationship of cinnamic acid esters and their derivatives as potential antifungal agents for plant protection. PloS one. 2017;12(4):e0176189. [Content Brief]
[2]. Charpentier J, et al. Effect of Fluorination on Skin Sensitization Potential and Fragrant Properties of Cinnamyl Compounds. Chemistry & biodiversity. 2018 Apr;15(4):e1800013. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ethyl 2-fluorocinnamate Related Classifications
HY-184778 Related Classifications
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