EPHA4 - EPH receptor A4 Gene

Also Known as EK8; SEK; HEK8; TYRO1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2043

About EPHA4

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:221,418,027-221,574,202 (from NCBI)

This gene has 14 transcripts (splice variants), 235 orthologues, 53 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 16.1), testis (RPKM 9.3) and 17 other tissues.

Summary

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

EPHA4 Products (4)

mRNA	Protein	Name
NM_001304536.2	NP_001291465.1	ephrin type-A receptor 4 isoform a precursor
NM_001304537.2	NP_001291466.1	ephrin type-A receptor 4 isoform b
NM_001363748.2	NP_001350677.1	ephrin type-A receptor 4 isoform c precursor
NM_004438.5	NP_004429.1	ephrin type-A receptor 4 isoform a precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables DH domain binding	IDA IDA: Inferred from direct assay	12775584	GOA
enables PH domain binding	IPI IPI: Inferred from physical interaction	12775584	GOA
enables kinase activity	IGI IGI: Inferred from genetic interaction	24217950	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12775584	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	12775584	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	24217950	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in ephrin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	29093007	GOA
involved in negative regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	29093007	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	22996586	GOA
acts upstream of or within negative regulation of cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	31150684	GOA
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	29093007	GOA
involved in negative regulation of proteolysis involved in protein catabolic process	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	12775584	GOA
involved in positive regulation of Rho guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	12775584	GOA
involved in positive regulation of amyloid-beta formation	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	22996586	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	28795314	GOA
involved in positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	28795314	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	12775584	GOA
involved in protein stabilization	IGI IGI: Inferred from genetic interaction	24217950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHA4 Protein Structure

Ephrin_lbd

fn3

EphA2_TM

Pkinase_Tyr

SAM_2

0
200
400
600
800
986 a.a.

Protein Preferred Names	Protein Names
ephrin type-A receptor 4	EPH-like kinase 8

EPHA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	EPHA4	P54764	EPHB2	Homo sapiens	P29323	Anti Tag CoIP	35384245
Intra	EPHA4	P54764	EPHB2	Homo sapiens	P29323	Affinity Chrom	35384245
Intra	EPHA4	P54764	EFNA5	Homo sapiens	P52803	X-Ray Diffraction	23812375
Intra	EPHA4	P54764	EFNA5	Homo sapiens	P52803	SPR	19836338
Intra	EPHA4	P54764	FABP1	Homo sapiens	P07148	Anti Tag CoIP	33961781
Intra	EPHA4	P54764	FABP1	Homo sapiens	P07148	Anti Tag CoIP	28514442
Intra	EPHA4	P54764	EFNB3	Homo sapiens	Q15768	X-Ray Diffraction	23812375
Intra	EPHA4	P54764	EFNA4	Homo sapiens	P52798	SPR	19836338
Intra	EPHA4	P54764	EFNB2	Homo sapiens	P52799	Pull Down	19836338
Intra	EPHA4	P54764	EFNB2	Homo sapiens	P52799	SPR	19836338
Intra	EPHA4	P54764	EFNB2	Homo sapiens	P52799	GMS	19836338
Intra	EPHA4	P54764	EFNB2	Homo sapiens	P52799	X-Ray Diffraction	19836338
Intra	EPHA4	P54764	EFNA2	Homo sapiens	O43921	X-Ray Diffraction	19836338
Intra	EPHA4	P54764	EFNA2	Homo sapiens	O43921	SPR	19836338
Intra	EPHA4	P54764	EFNA2	Homo sapiens	O43921	Pull Down	19836338
Intra	EPHA4	P54764	EFNA2	Homo sapiens	O43921	GMS	19836338

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHA4 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P70382	EphA4 Protein, Human (HEK293)	P54764-1 (V20-T547)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72993	EphA4 Protein, Human (Active, sf9, His-GST)	P54764-1 (S570-V986)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72994	EphA4 Protein, Human (HEK293, His-Fc)	P54764-1/NP_004429.1 (V20-T547)	≥ 90%, as determined by reducing SDS-PAGE.

EPHA4 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P85139	EphA3 Antibody (YA4831)	WB, ICC/IF, IP, ELISA, IF-Tissue	Human, Mouse, Rat
HY-P85140	Ephrin Receptor A4 Antibody (YA4832)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Duane Retraction Syndrome	Stilling-Turk-Duane Syndrome Duane'S Syndrome Duane Syndrome Isolated Duane Retraction Syndrome Co-Contractive Retraction Syndrome Duane Anomaly, Isolated Ocular Retraction Syndrome Drs Durs
Spondylocostal Dysostosis	Jarcho-Levin Syndrome Costovertebral Dysplasia Spondylothoracic Dysostosis Spondylothoracic Dysplasia Scdo Dysostosis, Spondylocostal
Staphyloenterotoxemia	Staphylococcal Food Poisoning Staphylococcal Toxaemia Due To Food Staphyloenterotoxicosis
Dysostosis	Dysostoses
Craniofrontonasal Syndrome	Craniofrontonasal Dysplasia CFNS Cfnd Craniofrontonasal Dysostosis Craniofrontonasal Dystosis Dysplasia, Craniofrontonasal
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Commensal Bacterial Infectious Disease
Deafness, X-Linked 2	Progressive Deafness With Stapes Fixation DFNX2 Dfn3 Nance Deafness Perilymphatic Gusher-Deafness Syndrome Stapedo-Vestibular Ankylosis Sensorineural Deafness, Profound, With Or Without A Conductive Component, Associated With A Unique Developmental Abnormality Of The Ear X-Linked Deafness 2 X-Linked Mixed Conductive And Neurosensory Deafness X-Linked Mixed Conductive And Sensorineural Deafness Deafness 3 Conductive With Stapes Fixation Deafness Conductive With Stapes Fixation Deafness Mixed With Perilymphatic Gusher Thies-Reis Syndrome Deafness, Conductive, With Stapes Fixation Deafness 3, Conductive, With Stapes Fixation Deafness, Mixed, With Perilymphatic Gusher Conductive Deafness 3 With Stapes Fixation Conductive Deafness With Stapes Fixation Mixed Deafness With Perilymphatic Gusher X-Linked Deafness Type 2 X-Linked Mixed Conductive And Neurosensory Hearing Loss X-Linked Mixed Conductive And Sensorineural Hearing Loss X-Linked Sensorineural Deafness X-Linked Stapes Gusher Syndrome Deafness Mixed With Perilymphatic Gusher, X-Linked Dfn 3 Nonsyndromic Hearing Loss And Deafness Gusher Syndrome Thies Reis Syndrome Progressive Hearing Loss With Stapes Fixation Deafness, X-Linked, 2 Deafness Mixed With Perilymph Gusher X-Linked Deafness, X-Linked, Type 2 Progressive Hearing Loss Stapes Fixation
Charcot-Marie-Tooth Disease, Axonal, Type 2dd	CMT2DD Charcot-Marie-Tooth Neuropathy, Type 2dd Charcot-Marie-Tooth Disease Type 2dd Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Atp1a1-Related Cmt2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd Charcot-Marie-Tooth Disease 2dd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-N0387	Rhynchophylline	Inhibitor	99.75%	Unkown
HY-P0177	123C4	Agonist	99.46%	Unkown
HY-P2264	KYL peptide	Inhibitor	99.65%	Unkown
HY-P11035	APY-d3	Inhibitor	99.18%	Unkown
HY-146375	UniPR505	Antagonist	99.68%	Unkown
HY-P10579	123B9	Agonist	99.67%	Unkown
HY-W078239	EPHA4 antagonist-1	Antagonist	95.61%	Unkown
HY-10654	EphB4-IN-2	Inhibitor	/	Unkown
HY-159174	EPHA2/A4/GAK-IN-1	Inhibitor	/	Unkown
HY-P11015	(123B9)2-Motif	Agonist	/	Unkown
HY-P11243	EphA4 agonist compound 23	Agonist	/	Unkown
HY-P11244	150D4	Agonist	/	Unkown
HY-RS04428	EPHA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17700	Epha4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24162	Epha4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P991974	Anti-EPHA4 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EPHA4	MGD	MGI:98277
Bos taurus	EPHA4	VGNC	VGNC:56106
Canis familiaris	EPHA4	VGNC	VGNC:40407
Macaca mulatta	EPHA4	VGNC	VGNC:72237
Rattus norvegicus	EPHA4	RGD	RGD:1560587
Felis catus	EPHA4	VGNC	VGNC:61904
Others	EPHA4	NCBI