1. Protein Tyrosine Kinase/RTK
  2. Ephrin Receptor
  3. KYL peptide

KYL peptide 

Cat. No.: HY-P2264
Handling Instructions

KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor. KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses.

For research use only. We do not sell to patients.

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KYL peptide Chemical Structure

KYL peptide Chemical Structure

CAS No. : 676657-00-4

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Description

KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor. KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses[1][2].

IC50 & Target

EphA4 receptor[1]

In Vitro

KYL peptide blocks the extracellular ligand-binding domain of EphA4, abolishes the Aβ-stimulated EphA4 tyrosine phosphorylation[2].
KYL peptide abolishes the Aβ-triggered reduction of dendritic spines in cultured hippocampal neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1465.73

Formula

C₇₄H₁₀₈N₁₄O₁₇

CAS No.
Sequence Shortening

KYLPYWPVLSSL

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
KYL peptide
Cat. No.:
HY-P2264
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