2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor
  4. KYL peptide

KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC50:4.22 μM, Kd:1.3 μM). KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

KYL peptide Chemical Structure

KYL peptide Chemical Structure

CAS No. : 676657-00-4

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1 mg USD 180 In-stock
5 mg USD 450 In-stock
10 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

KYL peptide Related Antibodies

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Description

KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC50:4.22 μM, Kd:1.3 μM). KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses[1][2][3].

IC50 & Target[3]

EphA4

4.22 μM μM (IC50)

EphA4

1.30 μM (Ki)

In Vitro

KYL peptide blocks the extracellular ligand-binding domain of EphA4, abolishes the Aβ-stimulated EphA4 tyrosine phosphorylation[2].
KYL peptide abolishes the Aβ-triggered reduction of dendritic spines in cultured hippocampal neurons[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KYL peptide Related Antibodies
Molecular Weight

1465.73

Formula

C74H108N14O17
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

KYLPYWPVLSSL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 55 mg/mL (37.52 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6823 mL 3.4113 mL 6.8225 mL
5 mM 0.1365 mL 0.6823 mL 1.3645 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6823 mL 3.4113 mL 6.8225 mL 17.0563 mL
5 mM 0.1365 mL 0.6823 mL 1.3645 mL 3.4113 mL
10 mM 0.0682 mL 0.3411 mL 0.6823 mL 1.7056 mL
15 mM 0.0455 mL 0.2274 mL 0.4548 mL 1.1371 mL
20 mM 0.0341 mL 0.1706 mL 0.3411 mL 0.8528 mL
25 mM 0.0273 mL 0.1365 mL 0.2729 mL 0.6823 mL
30 mM 0.0227 mL 0.1137 mL 0.2274 mL 0.5685 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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KYL peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KYL peptide676657-00-4Ephrin ReceptorEphA4AβADimmuneInhibitorinhibitorinhibit

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