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Cat. No.: HY-182625

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GS-1160-180

GS-1160-180 is a PAF receptor antagonist. GS-1160-180 competes with PAF for receptor binding, with no activity against collagen or adenosine diphosphate-induced platelet aggregation. GS-1160-180 can be used for research on asthma, anaphylactic shock, gastric ulceration, and transplant rejection.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 111878-47-8
Formule: C₃₃H₅₉BrN₂O₄S
Masse moléculaire:659.80

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GS-1160-180 Chemical Structure

CAS No.: 111878-47-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

In Vitro

GS-1160-180 (Compound 10) (100 nM; 3 min) competitively and specifically inhibits PAF-induced platelet aggregation in rabbit platelet-rich plasma, and shows no aggregation-inducing activity or off-target inhibition at concentrations ≤100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GS-1160-180 (Compound 10) (0.1 mg/kg; i.v.; single dose) exhibits potent inhibition of PAF-induced bronchoconstriction in guinea pigs, with an ED₅₀ of 0.1 mg/kg i.v^[1].
GS-1160-180 (0.5 mg/kg; i.v.; single dose) inhibits PAF-induced hypotension in rats, with an ED₅₀ of 0.5 mg/kg i.v^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 111878-47-8
Masse moléculaire 659.80
Formule C₃₃H₅₉BrN₂O₄S
SMILES

O=C(NCCCCCCCCCCCCCCCCCC)OCC(COC(CCCCCC[N+]1=CSC=C1)=O)=C.[Br-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Grue-Sørensen G, et al. Derivatives of 2-methylenepropane-1,3-diol as new antagonists of platelet activating factor. J Med Chem. 1988;31(6):1174-1178. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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