L-Ala-BPA
Based on 1 Customer Validation
L-Ala-BPA is a boron delivery agent. L-Ala-BPA is transported into tumor cells via PEPT1/2 and LAT-1 (SLC7A5) pathways and is rapidly cleaved systemically by endogenous proteases including FAP to yield L-BPA (HY-W087830). L-Ala-BPA shows antitumor activity and can be used for the research of Boron Neutron Capture Therapy (BNCT).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.0%
- CAS No.: 2941355-27-5
- Formule: C12H17BN2O5
- Masse moléculaire:280.08
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
L-Ala-BPA (2 h) mediates dose-dependent boron uptake in AsPC-1 cells via the PEPT1/2 transport pathway[1].
L-Ala-BPA (2 h) mediates dose-dependent boron uptake in FaDu cells via the LAT-1 transport pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Colon carcinoma BALB/c mice[1]
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Dosage:200 mg/kg
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Administration:i.v.; single bolus dose; 90 minutes prior to neutron irradiation
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Result:Induced complete and durable tumor control through the study endpoint.
Produced a 34% growth delay in non-irradiated abscopal tumors.
Chemical Information
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CAS No. 2941355-27-5
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Appearance Solid
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Masse moléculaire 280.08
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Formule C12H17BN2O5
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Color White to off-white
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SMILES
OB(O)C1=CC=C(C[C@H](NC([C@H](C)N)=O)C(O)=O)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-Ala-BPA Related Classifications
HY-183513 Related Classifications
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