Mpro/PLpro-IN-1
Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of Mpro/PLpro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus Mpro (IC50 = 1.72 μM) and submicromolar potency versus PLpro (IC50 = 0.67 μM).
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- CAS No.: 2766185-78-6
- Formule: C25H27ClN4O3
- Masse moléculaire:466.96
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
>50 μM
Compound: CV11
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth by coulter counter method
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth by coulter counter method
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[PMID: 38232463] |
| Vero | CC50 |
38.67 μM
Compound: 29
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by coulter counter method
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by coulter counter method
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[PMID: 34571172] |
| Vero | EC50 |
1.37 μM
Compound: 29
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Antiviral activity against Severe acute respiratory syndrome coronavirus 2 UC-1075 infected in African green monkey Vero cells assessed as reduction in plaque formation measured after 5 days by microscopic analysis
Antiviral activity against Severe acute respiratory syndrome coronavirus 2 UC-1075 infected in African green monkey Vero cells assessed as reduction in plaque formation measured after 5 days by microscopic analysis
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[PMID: 34571172] |
Chemical Information
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CAS No. 2766185-78-6
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Masse moléculaire 466.96
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Formule C25H27ClN4O3
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SMILES
C=CC[C@H](NC(CCl)=O)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(NCC3=CC=CC=C3)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mpro/PLpro-IN-1 Related Classifications
HY-144648 Related Classifications
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